'Obesities': Position statement on a complex disease entity with multifaceted drivers. (12th May 2022)

• Record Type: Journal Article
• Authors: Yárnoz‐Esquiroz, Patricia; Olazarán, Laura; Aguas‐Ayesa, Maite; Perdomo, Carolina M.; García‐Goñi, Marta; Silva, Camilo; Fernández‐Formoso, José Antonio; Escalada, Javier; Montecucco, Fabrizio; Portincasa, Piero; Frühbeck, Gema
• Is Part Of: European journal of clinical investigation. Volume 52:Number 7(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-12
• Subjects: dysfunctional adipose tissue -- metabolically healthy obesity -- non‐communicable diseases (NCDs) -- Obesity phenotypes -- precision medicine -- Sarcopenic obesity; Pathology -- Periodicals; Medical research -- Periodicals; 616.075
• DOI: 10.1111/eci.13811
• Languages: English
• ISSNs: 0014-2972

Abstract

Abstract: Academic medicine fosters research that moves from discovery to translation, at the same time as promoting education of the next generation of professionals. In the field of obesity, the supposed integration of knowledge, discovery and translation research to clinical care is being particularly hampered. The classification of obesity based on the body mass index does not account for several subtypes of obesity. The lack of a universally shared definition of "obesities" makes it impossible to establish the real burden of the different obesity phenotypes. The individual's genotype, adipotype, enterotype and microbiota interplays with macronutrient intake, appetite, metabolism and thermogenesis. Further investigations based on the concept of differently diagnosed "obesities" are required.