Safety of glucose‐6 phosphate dehydrogenase deficient donors in living right lobe liver donation. Issue 6 (13th March 2022)

• Record Type: Journal Article
• Authors: Dogar, Abdul Wahab; Ullah, Kaleem; Ghaffar, Abdul; Ud‐din, Shams‐; Hussain, Azhar; Ahmed, Hafiz Bilal; Abbas, Syed Hasnain; Ud‐din, Siraj; Hamza, Muhammad Ameer; Husnain, Ali; Shoaib, Azam; Ahmed, Bilal; Raza, Hamid; Zafar, Munaza; Baig, Muhammad Asif; Qaiser, Muhammad Affan; Shahwani, Asmat Ullah; Gupta, Subhash
• Is Part Of: Clinical transplantation. Volume 36:Issue 6(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-13
• Subjects: donors and donation -- liver transplantation -- living donor -- living donor hepatectomy; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ctr.14627
• Languages: English
• ISSNs: 0902-0063

Abstract

Abstract: Background: The literature lacks data on World Health Organization (WHO) class II and III deficient liver donors who underwent right hepatectomy during living donor liver transplantation (LDLT). Methods: In this prospective cohort study, we compared the perioperative outcomes of 15 glucose‐6 phosphate dehydrogenase (G6PD) deficient living liver donors with a matched cohort of 39 nondeficient living liver donors undergoing right lobe donation. Results: Out of 15 G6PD deficient donors, four (26.67%) donors had class II, and 11 (73.34%) had class III G6PD deficiency. The mean postoperative trough hemoglobin level was significantly lower in the deficient group than the nondeficient group (9.38 ± 1.59 g/dL vs. 10.27 ± .91 g/dL, p = .046). The mean peak indirect bilirubin level was significantly higher in the deficient group than the nondeficient group (2.22 ± 1.38 mg/dL vs. 1.40 ± .89 mg/dL, p = .047), and a similar trend was observed in total serum bilirubin (3.99 ± 2.57 mg/dL vs. 2.99 ± 1.46 mg/dL, p = .038). Biochemical evidence of hemolysis was found only in three (20%) deficient donors, but none of them needed a blood transfusion. No mortality was observed in either group. All other parameters, including demographics, operative parameters, graft characteristics, and hospital stay were comparable between both groups ( p > .05). Conclusion: G6PD deficiency with WHO class II and above should not be considered a contraindication for right lobe donation.