Handgrip strength and all‐cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study. Issue 3 (21st April 2022)

• Record Type: Journal Article
• Authors: Esteban‐Cornejo, Irene; Ho, Frederick K.; Petermann‐Rocha, Fanny; Lyall, Donald M.; Martinez‐Gomez, David; Cabanas‐Sánchez, Verónica; Ortega, Francisco B.; Hillman, Charles H.; Gill, Jason M.R.; Quinn, Terence J.; Sattar, Naveed; Pell, Jill P.; Gray, Stuart R.; Celis‐Morales, Carlos
• Is Part Of: Journal of cachexia, sarcopenia and muscle. Volume 13:Issue 3(2022)
• Page Start: 1514
• Page End: 1525
• Publication Date: 2022-04-21
• Subjects: Alzheimer -- Vascular dementia -- Muscular strength -- Prevention -- Adults -- Mortality; Cachexia -- Periodicals; Muscles -- Aging -- Periodicals; Muscles -- Periodicals; Cachexia; Sarcopenia; Muscles; Cachexia; Muscles; Muscles -- Aging; Periodicals; Periodicals; 616
• DOI: 10.1002/jcsm.12857
• Languages: English
• ISSNs: 2190-5991

Abstract

Abstract: Background: This study aimed to investigate the associations of grip strength with incidence and mortality from dementia and whether these associations differ by sociodemographic and lifestyle factors. Methods: A total of 466 788 participants of the UK Biobank (median age 56.5 years, 54.5% women). The outcome was all‐cause dementia incidence and mortality and the exposure was grip strength. Grip strength was assessed using a Jamar J00105 hydraulic hand dynamometer. Results: Excluding the first 2 years of follow‐up (landmark analysis), mean follow‐up was 9.1 years (inter‐quartile range: 8.3; 9.7) for incidence and 9.3 (inter‐quartile range: 8.7; 10.0) for mortality. During this time, 4087 participants developed dementia, and 1309 died from it. Lower grip strength was associated with a higher risk of dementia incidence and mortality independent of major confounding factors ( P < 0.001). Individuals in the lowest quintile of grip strength had 72% [95% confidence interval (CI): 1.55; 1.92] higher incident dementia risk and 87% [95% CI: 1.55; 2.26] higher risk of dementia mortality compared with those in the highest quintile. Our PAF analyses indicate that 30.1% of dementia cases and 32.3% of dementia deaths are attributable to having low grip strength. The association between grip strength and dementia outcomes did not differ by lifestyle or sociodemographic factors. Conclusions: Lower grip strength was associated with a higher risk of all‐cause dementia incidence and mortality, independently of important confounding factors.