A new benzophenone, and the antiplasmodial activities of the constituents of Securidaca longipedunculata fresen (Polygalaceae). Issue 11 (2nd June 2022)

• Record Type: Journal Article
• Authors: Ochora, Douglas O.; Kakudidi, Esezah; Namukobe, Jane; Heydenreich, Matthias; Coghi, Paolo; Yang, Li Jun; Mwakio, Edwin W.; Andagalu, Ben; Roth, Amanda; Akala, Hoseah M.; Wong, Vincent K. W.; Yenesew, Abiy
• Is Part Of: Natural product research. Volume 36:Issue 11(2022)
• Page Start: 2758
• Page End: 2766
• Publication Date: 2022-06-02
• Subjects: Antiplasmodial -- benzophenone -- cytotoxicity -- ex vivo -- Securidaca longipedunculata -- 2, 3, 4, 5-tetramthoxybenzophenone; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1925272
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Extracts from Securidaca longipedunculata showed antiplasmodial activities against reference clones and clinical isolates using SYBR Green I method. A new benzophenone, 2, 3, 4, 5-tetramethoxybenzophenone (1 ) was isolated and characterized along with seven known compounds: 4-hydroxy-2, 3-dimethoxybenzophenone (2 ); 3-hydroxy-5-methoxybiphenyl (3 ), methyl-2-hydroxy-6-methoxybenzoate (4 ), benzyl-2-hydroxy-6-methoxybenzoate (5 ), 2-hydroxy-6-methoxybenzoic acid (6 ), 2, 4, 5-trimethoxybenzophenone (7 ) and 2-methoxy-3, 4-methylenedioxybenzophenone (8 ). Compounds 1 and 2 showed ex vivo antiplasmodial activities (IC50 28.8 μM and 18.6 μM, respectively); while 5 and 8 showed in vivo activities (IC50 19.7 μM and 14.5 μM, respectively) against D6 strain. In a cytotoxicity assay, all the extracts (with an exception of the MeOH extract of the leaves) and pure compounds were not toxic to the normal LO2 and BEAS cell-lines, while the methanol roots extract (IC50 66.4 µg/mL against A549, and 77.4 µg/mL against HepG2), compounds 6 (IC50 22.2 µM against A549) and 7 (IC50 45.2 µM against HepG2) were weakly active against cancerous cell-lines. Graphical Abstract: UF0001