Lenticular changes in eyes with advanced intraocular retinoblastoma: A histopathological study of 48 enucleated eyes. (19th May 2022)

• Record Type: Journal Article
• Authors: Jakati, Saumya; Vempuluru, Vijitha S; Mohamed, Ashik; Mishra, Dilip K; Kaliki, Swathi
• Is Part Of: Seminars in ophthalmology. Volume 37:Number 4(2022)
• Page Start: 480
• Page End: 484
• Publication Date: 2022-05-19
• Subjects: Eye lens -- Cataract -- Histopathology -- High-risk features -- Retinoblastoma -- Necrosis; Ophthalmology -- Periodicals; Eye -- Diseases -- Periodicals; Eye -- Surgery -- Periodicals; 617.7005
• DOI: 10.1080/08820538.2021.1962367
• Languages: English
• ISSNs: 0882-0538

Abstract

ABSTRACT: Purpose: To evaluate the lenticular changes in advanced intraocular retinoblastoma (RB) and identify the risk factors for cataract in these eyes. Methods: Retrospective analysis of 48 primary enucleations. Results: All enucleated eyes were classified either as group D (n = 7; 15%) or group E (n = 41; 85%) tumors based on the International Classification of Intraocular Retinoblastoma. Of the 48 enucleated eyes with RB, cataract was noted clinically in only 5 (18%) cases, while histopathology revealed cataractous changes in 28 (58%) cases. Based on histopathology, the cataractous changes included anterior subcapsular cataract ( n = 10; 36%), cortical cataract ( n = 6; 21%), posterior subcapsular cataract ( n = 10; 36%) and both anterior and posterior subcapsular cataract ( n = 2; 7%). Based on multivariate logistic regression, only increased area of necrosis on histopathology was the significant ( p = .009) factor predictive of cataractous changes in lens with an odds ratio of 1.08. Conclusion: Eyes with advanced RB can harbor cataract in 58% cases, though most of these are subclinical. Clinically significant cataract may be evident in only 18% cases. Increased tumor necrosis is associated with the development of cataractous changes in RB cases.