A methodological approach for the synthesis of 4-aryl-8-arylidene-2-cyanoimino-1, 2, 3, 4, 5, 6, 7, 8-octahydroquinazolines. Issue 8 (18th April 2022)

• Record Type: Journal Article
• Authors: Moustafa, Amr H.; Hussein, Bahgat R. M.
• Is Part Of: Synthetic communications. Volume 52:Issue 8(2022)
• Page Start: 1131
• Page End: 1138
• Publication Date: 2022-04-18
• Subjects: Cyanoguanidine -- cyanoimino -- diarylidinecyclohexanone -- four-component reaction -- octahydroquinazoline; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2022.2072747
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: An efficient methodological approach for the synthesis of a novel series of 4-aryl-8-arylidene-2-cyanoimino-1, 2, 3, 4, 5, 6, 7, 8-octahydroquinazolines (aryl-CIOHQs) was presented via one-pot four-component reaction of cyclohexanone, two-folds of various aromatic aldehydes and cyanoguanidine in the presence of sodium ethoxide as basic catalyst. The same target products (aryl-CIOHQs) were also reproduced in good yields using an ordinary method via two-component reaction of 2, 6-diarylidinecyclohexanone derivatives with cyanoguanidine in the same condition. Graphical Abstract: UF0001