Smart nanocarrier-based chitosan @silica coated carbon nanotubes composite for breast cancer treatment approach. Issue 12 (13th August 2022)

• Record Type: Journal Article
• Authors: El-Shahawy, Ahmed A. G.; Elnagar, Noha; Zohery, Medhat; Abd Elhafeez, Maha Sabry; El-Dek, S. I.
• Is Part Of: International journal of polymeric materials. Volume 71:Issue 12(2022)
• Page Start: 910
• Page End: 922
• Publication Date: 2022-08-13
• Subjects: Carbon nanotubes -- chitosan -- doxorubicin -- silica -- drug delivery; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2021.1925277
• Languages: English
• ISSNs: 0091-4037

Abstract

Abstract: The nonspecificity of doxorubicin (DOX), as well as its oral bioavailability, is a major obstacle in the clinical setting. This study was based on the change of pH value and designed for the 1st time a novel nano-matrix; multiwall carbon nanotubes (MWCNTs) coated with mesoporous silica (MS) and chitosan (CS). The latter possessed a unique nanostructure with pH-sensitivity in DOX release to be administered orally for the treatment of breast cancer. The loaded DOX and entrapment efficiency reached 64% and 99%, respectively. The results of MWCNTs@MS@CS@DOX confirmed its efficiency as pH-based drug delivery for oral breast cancer therapy. Graphical Abstract: UF0001