A Cu(II)-based coordination polymer: catalytic properties and treatment activity on stroke. Issue 1 (31st December 2022)

• Record Type: Journal Article
• Authors: Gao, Peng-Ju; Liu, Ji-Rong
• Is Part Of: Designed monomers and polymers. Volume 25:Issue 1(2022)
• Page Start: 148
• Page End: 154
• Publication Date: 2022-12-31
• Subjects: Cu(II) compound -- infinite chain -- Mixed-ligand -- catalysis -- stroke; Monomers -- Periodicals; Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.7005
• DOI: 10.1080/15685551.2022.2086396
• Languages: English
• ISSNs: 1385-772X

Abstract

ABSTRACT: A fresh Cu(II) coordination polymer, i.e., [Cu3 (Hmbdc)2 (mbdc)2 (dmphen)2 ]n (1, H2 mbdc = isophthalic acid, dmphen = 4, 7-dimethyl-1, 10-phenanthroline), has been generated with the hydrothermal reactions between Cu salts and the mixed ligands of 4, 7-dimethyl-1, 10-phenanthroline and isophthalic acid. Moreover, the catalytic activity of 1 was evaluated via degrading the Congo red with a method of Fenton with an excellent degradation efficiency of 95.8% at 100 min. Next, the application value of compound on stroke was assessed, and the related mechanisms were explored at the same time. First of all, the tumor necrosis factor-α and recombinant rat IL-1β content released into the plasma were determined with enzyme-linked immunosorbent assay detection kit. Besides, the activation of the HMGB1/TLR4 signaling pathway activation in cerebral vascular endothelial cells was also determined with real-time reverse transcription–polymerase chain reaction assay.