Hexane extract from Spiranthera odoratissima A. St.-hil. leaves: chemical composition and its bioactive potential against Candida pathogenic species, Leishmania amazonensis and Xylella fastidiosa. Issue 11 (2nd June 2022)

• Record Type: Journal Article
• Authors: Souza, Amanda de O.; Pereira, Paulo S.; Fernandes, Cassia C.; Andrade, Géssica; Pires, Regina H.; Candido, Ana C. B. B.; Magalhães, Lizandra G.; Vieira, Tatiana M.; Crotti, Antônio E. M.; Martins, Carlos H. G.; Miranda, Mayker L. D.
• Is Part Of: Natural product research. Volume 36:Issue 11(2022)
• Page Start: 2907
• Page End: 2912
• Publication Date: 2022-06-02
• Subjects: Leishmania amazonensis -- Candida orthopsilosis -- Xylella fastidiosa -- spathulenol; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1931188
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Spiranthera odoratissima A. St.-Hil. (Rutaceae) has been popularly used against abdominal pain and rheumatism. This study aimed at extracting hexane from S. odoratissima (HE-SO) leaves to identify and quantify its volatile compounds by GC-MS and GC-FID and to evaluate its antifungal, antileishmanial and antibacterial activities in vitro . HE-SO exhibited antileishmanial activity against promastigote forms of Leishmania (Leishmania) amazonensis (IC50 = 38.16 µg/mL) and was moderately active against Xylella fastidiosa (MIC = 100 µg/mL). HE-SO also showed remarkable antifungal potential against six strains of Candida species, i. e., C. albicans, C. glabrata, C. parapsilosis, C. krusei, C. tropicalis and C. orthopsilosis . The lowest MIC values were between 31.25 and 250 µg/mL. Spathulenol (20.2%), τ-cadinol (11.7%), α-cadinol (9.4%), caryophyllene oxide (9.2%) and isoaromadendrene epoxide (8.2%) were the major components identified in HE-SO. Therefore, results showed that HE-SO has promising antileishmanial and antifungal actions. Graphical Abstract: UF0001