Chemical constituents from the stems of Acanthopanax senticosus with their cytotoxic activities. Issue 7 (3rd July 2022)

• Record Type: Journal Article
• Authors: Chen, Xian-Hua; Zhao, Yu-Ying; Wang, Qi; Li, Zhi-Ling; Li, Feng-Xia; Tan, Hong-Yu; Huang, Yue-Yue
• Is Part Of: Journal of Asian natural products research. Volume 24:Issue 7(2022)
• Page Start: 673
• Page End: 678
• Publication Date: 2022-07-03
• Subjects: Acanthopanax senticosus -- Araliaceae -- coumestan -- cytotoxic activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2021.1951713
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A new coumestan named 7, 5'-dihydroxy-4'-(3''-hydroxy-3''-methyl- trans -isobut-1''-enyl) coumestan (1 ), together with five known compounds (2–6 ), was isolated from the EtOAc-soluble extract of the stems of Acanthopanax senticosus . Their structures were elucidated based on extensive spectroscopic analyses. All the isolates were evaluated for in vitro cytotoxic activities against four human cancer cells including HepG2, A549, HeLa and MCF-7. Among them, the new compound 1 was found to exhibit significant cytotoxic activity on HeLa cells with IC50 value of 6.5 μM. Abstract : UF0001