Cytotoxic and genotoxic properties of artathomsonine, a new oxoberberine alkaloid from Artabotrys thomsonii (annonaceae). Issue 11 (2nd June 2022)

• Record Type: Journal Article
• Authors: Nguemdjo Chimeze, Valery Wilfried; Bankoglu, Ezgi Eyluel; Zühlke, Sebastian; Fannang, Véronique Simone; Eckelmann, Dennis; Chi Shirri, Jovita; Djuidje, Ernestine Nicaise; Djama, Céline Mbazoa; Stopper, Helga; Wandji, Jean
• Is Part Of: Natural product research. Volume 36:Issue 11(2022)
• Page Start: 2791
• Page End: 2799
• Publication Date: 2022-06-02
• Subjects: Artabotrys thomsonii -- oxoberberine alkaloid -- HRESI-MSn and NMR spectroscopy -- cytotoxicity -- genotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1928117
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A phytochemical investigation of the liana of Artabotrys thomsonii led to the isolation of a new oxoberberine alkaloid, 2, 10-dihydroxy-3, 9-dimethoxy-8-oxo-protoberberine (7 ), along with six known compounds. Their chemical structures were elucidated by 1 D and 2 D NMR spectroscopic methods and HRESI-MS n data analysis. Compounds 4 and 7 were selected for further in vitro investigations. In accordance with expectations from their chemical structures, compounds 7 and 4 showed a clear antioxidant activity in a cell-free assay, with compound 7 being 7-fold more active than 4 . Cytotoxicity, cytostatic and genotoxic effects only occurred at high micromolar concentrations of 50 µM or more. Compound 7 was slightly less effective than compound 4 . A low micromolar concentration of 10 µM did not cause any damaging cellular effects but showed potential for a protection against the micronucleus-inducing effect of reactive oxygen species hydrogen peroxide, although not to a significant extent. Graphical Abstract: UF0001