A mild and concise synthesis of aryloxy phosphoramidate prodrug of alcohols via transesterification reaction. Issue 21 (29th April 2022) - Ying, Hanglu
Abstract : A synthesis of aryloxy phosphoramidate prodrug of alcohols enabled by a transesterification strategy is described here. Abstract : A synthesis of aryloxy phosphoramidate prodrug of alcohols enabled by a transesterification strategy is described here. This reaction operates under mild conditions and thus has excellent functional group tolerance. This method provides an efficient and practical solution to the rapid construction of the aryloxy phosphoramidate prodrugs library for potential SAR studies.