Construction of multi-substituted pyrazoles via potassium carbonate-mediated [3 + 2] cycloaddition of in situ generated nitrile imines with cinnamic aldehydes. Issue 21 (29th April 2022)

• Record Type: Journal Article
• Authors: Li, Mei-Mei; Huang, Hui; Tian, Wanrong; Pu, Yiru; Zhang, Chaozheng; Yang, Jirui; Ren, Qing; Tao, Feiyan; Deng, Yun; Lu, Jun
• Is Part Of: RSC advances. Volume 12:Issue 21(2022)
• Page Start: 13087
• Page End: 13092
• Publication Date: 2022-04-29
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d2ra00331g
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A highly efficient potassium carbonate-mediated [3 + 2] cycloaddition reaction of hydrazonoyl chlorides with cinnamic aldehydes to furnish multi-substituted pyrazoles under nontoxic and mild conditions has been developed. Abstract : A highly efficient potassium carbonate-mediated [3 + 2] cycloaddition reaction of hydrazonoyl chlorides with cinnamic aldehydes to furnish multi-substituted pyrazoles under nontoxic and mild conditions has been developed. A plausible stepwise cycloaddition reaction mechanism is proposed. This protocol featured broad substrate coverage, good functional group tolerance, wide scalability, and operational simplicity, as well as conveniently constructed pyrazole scaffolds.