An autophagy-inhibitory MOF nanoreactor for tumor-targeted synergistic therapy. (26th May 2022) - Liu, Xiaohan
Abstract : A cell membrane-camouflaged MOF nanoreactor was developed for inhibiting autophagy and synergistically restraining tumor growth. Abstract : An autophagy-inhibitory metal–organic framework (MOF) nanoreactor was developed for tumor-targeted synergistic therapy. The nanoreactor could inhibit autophagy to enhance the glucose oxidase (GOx)-mediated starvation therapy. The H2 O2 generated in this process induced the polarization of macrophages to the M1 phenotype, which further enhanced the therapeutic effect.