A rational design of copper–selenium nanoclusters that cures sepsis by consuming endogenous H2S to trigger photothermal therapy and ROS burst. (12th May 2022)

• Record Type: Journal Article
• Authors: Gao, Yin; Wang, Zekun; Li, Yuqing; Yang, Jie; Liao, Ziyu; Liu, Jing; Guo, Feng; Yang, Endong; Wang, Weiyun; Sun, Dongdong
• Is Part Of: Biomaterials science. Volume 10:Number 12(2022)
• Page Start: 3137
• Page End: 3157
• Publication Date: 2022-05-12
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/d2bm00172a
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : Design and synthesis core–shell nanomaterials Se@Cu2 O, in situ sulfided Se@Cu2 O with endogenous H2 S to generate Se@Cu9 S8, synergistic antibacterial treatment of mouse sepsis by triggering ROS burst and photothermal effect. Abstract : The treatment of sepsis caused by bacterial infections is still a huge clinical challenge. As sepsis causes high levels of endogenous H2 S in vivo, researchers can design nanomedicines to treat sepsis by in situ sulfurization. Here, we designed and synthesized Cu2 O-coated non-metallic core–shell selenium nanoparticles. To cure mice sepsis by ROS burst. Our experimental data displayed that the photothermal effect of Se@Cu9 S8 produced by the reaction of Se@Cu2 O and endogenous H2 S is synergistically antibacterial, and Se@Cu2 O has the characteristics of low side effects and high biocompatibility. In summary, our research results verified our design, that copper–selenium nanoclusters may be an efficient strategy to cure sepsis by in situ sulfurization of endogenous H2 S, triggering ROS eruptions and photothermal therapy.