Exposomic determinants of immune-mediated diseases: Special focus on type 1 diabetes, celiac disease, asthma, and allergies: The HEDIMED project approach. Issue 3 (8th June 2022)

• Record Type: Journal Article
• Authors: Laiho, Jutta E.; Laitinen, Olli H.; Malkamäki, Johannes; Puustinen, Leena; Sinkkonen, Aki; Pärkkä, Juha; Hyöty, Heikki
• Other Names: Anna Eurén author non-byline.; Heikki Hyöty author non-byline.; Kalle Kurppa author non-byline.; Jutta Laiho author non-byline.; Olli Laitinen author non-byline.; Jussi Lehtonen author non-byline.; Katri Lindfors author non-byline.; Maria Lönnrot author non-byline.; Johannes Malkamäki author non-byline.; Henna Numminen author non-byline.; Noora Nurminen author non-byline.; Matti Nykter author non-byline.; Sami Oikarinen author non-byline.; Leena Puustinen author non-byline.; Niila Saarinen author non-byline.; Amirbabak Sioofy-Khojine author non-byline.; Keijo Viiri author non-byline.; Daniel Agardh author non-byline.; Andrén Aronsson Carin author non-byline.; Markus Lundgren author non-byline.; Iida Mäkelä author non-byline.; Martin Romantschuk author non-byline.; Laura Soininen author non-byline.; Lund-Blix Nicolai A. author non-byline.; Maria Magnus author non-byline.; Aino-Kaisa Rantala author non-byline.; Lars Stene author non-byline.; Ketil Størdal author non-byline.; German Tapia author non-byline.; Laura Elo author non-byline.; Sini Junttila author non-byline.; Riitta Lahesmaa author non-byline.; Johanna Lempainen author non-byline.; Robert Moulder author non-byline.; Omid Rasool author non-byline.; Tomi Suomi author non-byline.; Jorma Toppari author non-byline.; Ubaid Ullah author non-byline.; Riitta Veijola author non-byline.; Aleksandr Peet author non-byline.; Kärt Simre author non-byline.; Vallo Tillmann author non-byline.; Elena Bargagli author non-byline.; Francesco Dotta author non-byline.; Laura Nigi author non-byline.; Guido Sebastiani author non-byline.; Leena Hakola author non-byline.; Hannu Kiviranta author non-byline.; Panu Rantakokko author non-byline.; Suvi Virtanen author non-byline.; Ondrej Cinek author non-byline.; Eva Fronkova author non-byline.; Jaroslav Havlik author non-byline.; Emilia Barannik author non-byline.; Matthieu Molinier author non-byline.; Tarja Nevanen author non-byline.; Juha Pajula author non-byline.; Eija Parmes author non-byline.; Juha Pärkkä author non-byline.; Jukka Ranta author non-byline.; Jyri Rökman author non-byline.; Petri Saviranta author non-byline.; Peter Ylén author non-byline.; Alar Aints author non-byline.; Anu Bärenson author non-byline.; Anne Kirss author non-byline.; Ivo Laidmäe author non-byline.; Astrid Oras author non-byline.; Aili Tagoma author non-byline.; Raivo Uibo author non-byline.; Tamara Vorobjova author non-byline.; Loïc Burr author non-byline.; Stefano Cattaneo author non-byline.; Hui Chai-Gao author non-byline.; Peter Cristofollini author non-byline.; Silvia Generelli author non-byline.; Samantha Paoletti author non-byline.; Edith Ruth author non-byline.; Gabriele Berg author non-byline.; Wisnu Wicaksono author non-byline.; Kristi Hoffman author non-byline.; Joseph Petrosino author non-byline.; Schmidtmann Daniel author non-byline.; Rainer Thiel author non-byline.; Rosanna Salo author non-byline.; Lauri Häme author non-byline.; Alexander Berler author non-byline.; Apostolia Karabatea author non-byline.; Korina Papadopoulou author non-byline.; Hans Bisgaard author non-byline.; Klaus Bønnelykke author non-byline.; Sarah Brandt author non-byline.; Astrid Sevelsted author non-byline.; Jakob Stokholm author non-byline.; Jonathan Thorsen author non-byline.; Mikael Knip author non-byline.; Marja Roslund author non-byline.; Aki Sinkkonen author non-byline.;
• Is Part Of: Environmental epidemiology. Volume 6:Issue 3(2022)
• Page Start: e212
• Publication Date: 2022-06-08
• Subjects: Allergy -- Asthma -- Celiac disease -- Diet -- Interventions -- Microbiome -- OMICS -- Satellite data -- Toxicants -- Type 1 diabetes; Epidemiology -- Periodicals; Epidemiology -- Environmental aspects -- Periodicals; 614.4
• DOI: 10.1097/EE9.0000000000000212
• Languages: English
• ISSNs: 2474-7882

Abstract

Abstract : The incidence of immune-mediated diseases (IMDs) is increasing rapidly in the developed countries constituting a huge medical, economic, and societal challenge. The exposome plays an important role since genetic factors cannot explain such a rapid change. In the Human Exposomic Determinants of Immune Mediated Diseases (HEDIMED) project, altogether 22 academic and industrial partners join their multidisciplinary forces to identify exposomic determinants that are driving the IMD epidemic. The project is based on a combination of data and biological samples from large clinical cohorts constituting about 350, 000 pregnant women, 30, 000 children prospectively followed from birth, and 7, 000 children from cross-sectional studies. HEDIMED focuses on common chronic IMDs that cause a significant disease burden, including type 1 diabetes, celiac disease, allergy, and asthma. Exposomic disease determinants and the underlying biological pathways will be identified by an exploratory approach using advanced omics and multiplex technologies combined with cutting-edge data mining technologies. Emphasis is put on fetal and childhood exposome since the IMD disease processes start early. Inclusion of several IMDs makes it possible to identify common exposomic determinants for the diseases, thus facilitating the development of widely operating preventive and curative treatments. HEDIMED includes data and samples from birth cohorts and clinical trials that have used exposomic interventions and cell and organ culture models to identify mechanisms of the observed associations. Importantly, HEDIMED generates a toolbox that offers science-based functional tools for key stakeholders to control the IMD epidemic. Altogether, HEDIMED aims at innovations, which become widely exploited in diagnostic, therapeutic, preventive, and health economic approaches.