Comparison of a preservative-free nonsteroidal anti-inflammatory drug and preservative-free corticosteroid after uneventful cataract surgery: multicenter, randomized, evaluator-blinded clinical trial. Issue 6 (8th June 2022)

• Record Type: Journal Article
• Authors: Kim, Seonjoo; Ko, Byung-Yi; Koh, Jae Woong; Kim, Eun Chul; Kim, Hong Kyun; Shin, Young Joo; Song, Jong-Suk; Lee, Do Hyung; Lee, Ji Eun; Lee, Hyung Keun; Chung, So-Hyang; Kim, Hyun Seung
• Is Part Of: Journal of cataract and refractive surgery. Volume 48:Issue 6(2022)
• Page Start: 710
• Page End: 716
• Publication Date: 2022-06-08
• Subjects: 617.7
• DOI: 10.1097/j.jcrs.0000000000000841
• Languages: English
• ISSNs: 0886-3350

Abstract

Abstract : Preservative-free bromfenac was as effective as preservative-free fluorometholone eyedrops in anterior chamber inflammation control and showed better signs and symptoms profile after cataract surgery. Abstract : Purpose: To compare the efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) and steroidal eyedrops for inflammation management after cataract surgery using slitlamp indicators. Setting: 11 eye centers in South Korea. Design: Randomized prospective multicenter study with a blinded evaluator. Method: In 125 (250 eyes) patients who underwent cataract surgery, bromfenac sodium hydrate 0.1% (NSAID group) was applied twice a day in 1 eye, whereas the other eye was treated with fluorometholone 0.1% (steroid group), 4 times a day for 4 weeks postoperatively. The primary efficacy outcome was the presence of anterior chamber cells and flare at 1 week postoperatively. Anterior chamber cells and flare at 4 to 8 weeks, corrected distance visual acuity, central corneal thickness, conjunctival hyperemia, dry eye parameters, foveal thickness, and ocular and visual discomfort were evaluated as secondary outcomes. Results: At week 1, residual anterior chamber inflammation was not statistically significantly different between the groups (−1.03 ± 1.27 vs −0.95 ± 1.24, P = .4850). However, the NSAID group recovered from conjunctival hyperemia more rapidly than the steroid group (0.30 ± 0.52 vs 0.44 ± 0.81, P = .0144 at week 1). The increase in central corneal thickness in the NSAID group was less than that in the steroid group 1 week postoperatively (7.87 ± 22.46 vs 29.47 ± 46.60 μm, P < .0001). The change in foveal thickness in the NSAID group was significantly less than that in the steroid group (18.11 ± 68.19 vs 22.25 ± 42.37 μm, P = .0002). Lower levels of postoperative ocular and visual discomfort were reported in the NSAID group than in the steroid group under treatment. Conclusions: Preservative-free bromfenac was as effective as preservative-free fluorometholone eyedrops in anterior chamber inflammation control and showed better signs and symptoms after cataract surgery.