SARS-CoV-2 Testing and Positivity Among Persons With and Without HIV in 6 US Cohorts. (1st July 2022)

• Record Type: Journal Article
• Authors: Park, Lesley S.; McGinnis, Kathleen A.; Gordon, Kirsha S.; Justice, Amy C.; Leyden, Wendy; Silverberg, Michael J.; Skarbinski, Jacek; Jefferson, Celeena; Horberg, Michael; Certa, Julia; Napravnik, Sonia; Edwards, Jessie K.; Westreich, Daniel; Bastarache, Lisa; Gangireddy, Srushti; Benning, Lorie; D'Souza, Gypsyamber; Williams, Carolyn; Althoff, Keri N.
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 90:Number 3(2022)
• Page Start: 249
• Page End: 255
• Publication Date: 2022-07-01
• Subjects: COVID-19 -- SARS-CoV-2 -- testing -- HIV; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/QAI.0000000000002943
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Supplemental Digital Content is Available in the Text. Abstract : Background: It is not definitively known if persons with HIV (PWH) are more likely to be SARS-CoV-2 tested or test positive than persons without HIV (PWoH). We describe SARS-CoV-2 testing and positivity in 6 large geographically and demographically diverse cohorts of PWH and PWoH in the United States. Setting: The Corona Infectious Virus Epidemiology Team comprises 5 clinical cohorts within a health system (Kaiser Permanente Northern California, Oakland, CA; Kaiser Permanente Mid-Atlantic States, Rockville, MD; University of North Carolina Health, Chapel Hill, NC; Vanderbilt University Medical Center, Nashville, TN; and Veterans Aging Cohort Study) and 1 interval cohort (Multicenter AIDS Cohort Study/Women's Interagency HIV Study Combined Cohort Study). Methods: We calculated the proportion of patients SARS-CoV-2 tested and the test positivity proportion by HIV status from March 1 to December 31, 2020. Results: The cohorts ranged in size from 1675 to 31, 304 PWH and 1430 to 3, 742, 604 PWoH. The proportion of PWH who were tested for SARS-CoV-2 (19.6%–40.5% across sites) was significantly higher than PWoH (14.8%–29.4%) in the clinical cohorts. However, among those tested, the proportion of patients with positive SARS-CoV-2 tests was comparable by HIV status; the difference in proportion of SARS-CoV-2 positivity ranged from 4.7% lower to 1.4% higher. Conclusions: Although PWH had higher testing proportions compared with PWoH, we did not find evidence of increased positivity in 6 large, diverse populations across the United States. Ongoing monitoring of testing, positivity, and COVID-19–related outcomes in PWH are needed, given availability, response, and durability of COVID-19 vaccines; emergence of SARS-CoV-2 variants; and latest therapeutic options.