High-dose intravenous iron supplementation after preoperative autologous blood donation is useful to prevent post-donation/preoperative anemia. (June 2022)

• Record Type: Journal Article
• Authors: Ikeda, Toshiyuki; Terada, Rui; Nagura, Yutaka; Okazaki, Hitoshi
• Is Part Of: Transfusion and apheresis science. Volume 61:Number 3(2022)
• Publication Date: 2022-06
• Subjects: ABT allogeneic blood transfusion -- ATR adverse transfusion reaction -- CI confidence interval -- DM diabetes mellitus -- FNHTR febrile non-hemolytic transfusion reaction -- Hb hemoglobin -- HTR hemolytic transfusion reaction -- IDA iron deficiency anemia -- IV intravenous -- JSTMCT the Japan Society of Transfusion Medicine and Cell Therapy -- MSBOS maximum surgical blood order schedule -- PAD preoperative autologous blood donation -- RA rheumatoid arthritis -- TRALI transfusion-related acute lung injury -- TRIM transfusion-related immunomodulation -- TSAT transferrin saturation -- TTI transfusion-transmitted infection -- VTE venous thromboembolism; Preoperative autologous blood donation -- Preoperative anemia -- Post-donation anemia -- Intravenous iron supplementation; Blood -- Transfusion -- Periodicals; Hemapheresis -- Periodicals; 615.39
• DOI: 10.1016/j.transci.2021.103348
• Languages: English
• ISSNs: 1473-0502

Abstract

Highlights: High-dose intravenous iron in preoperative autologous donation was evaluated. High-dose intravenous iron may increase the preoperative hemoglobin value. It may also decrease the hemoglobin change ratio during donation. Abstract: To estimate the effectiveness of high-dose intravenous (IV) iron supplementation for iron deficiency anemia after preoperative autologous blood donation (PAD), 155 donors who visited the donation office of the University of Tokyo Hospital from December 2020 to June 2021 and showed suspected post-donation anemia were analyzed. The participants were treated with high-dose intravenous (IV) iron supplementation (high-dose group, n = 30) or a combination of low-dose IV iron and oral iron supplementation (low-dose group, n = 125). The preoperative hemoglobin (Hb) and Hb decreasing ratios during PAD (ΔHb) were compared between the two groups. Multivariate linear regression analyses were also performed to identify the confounding factors associated with preoperative Hb and ΔHb as well as high-dose IV iron supplementation. Preoperative Hb level was slightly higher in the high-dose group than in the low-dose group (12.1 ± 1.1 vs. 11.9 ± 1.1 g/dL, p = 0.27). ΔHb was significantly higher in the high-dose group than in the low-dose group (3.7 % ± 8.8 % vs. 7.7 % ± 6.5 %, p = 0.011). On the multivariate linear regression analyses, high-dose IV iron supplementation was significantly associated with higher preoperative Hb and lower ΔHb levels (p = 0.021 and 0.017, respectively) as well as the donation available period (period from the first visit to the donation office to the operation) and administration of erythropoiesis-stimulating agents. High-dose IV iron supplementation after PAD will be useful in the treatment of post-donation anemia.