A comparison of Remdesivir versus gold cluster in COVID-19 animal model: A better therapeutic outcome of gold cluster. (June 2022)

• Record Type: Journal Article
• Authors: He, Zhesheng; Ye, Fei; Zhang, Chunyu; Fan, Jiadong; Du, Zhongying; Zhao, Wencong; Yuan, Qing; Niu, Wenchao; Gao, Fuping; He, Bo; Cao, Peng; Zhao, Lina; Gao, Xuejiao; Gao, Xingfa; Sun, Bo; Dong, Yuhui; Zhao, Jincun; Qi, Jianxun; Liang, Xing-Jie; Jiang, Huaidong; Gong, Yong; Tan, Wenjie; Gao, Xueyun
• Is Part Of: Nano today. Volume 44(2022)
• Publication Date: 2022-06
• Subjects: COVID-19 -- SARS-CoV-2 -- Gold cluster -- Viral replication -- Inflammatory cytokine; Nanotechnology -- Periodicals; Nanosciences -- Périodiques; 620.505
• DOI: 10.1016/j.nantod.2022.101468
• Languages: English
• ISSNs: 1748-0132

Abstract

Abstract: While gold compound have been approved for Rheumatoid arthritis treatment as it well suppresses inflammatory cytokines of patients, no such treatment is currently available for COVID-19 treatment in vivo . We firstly disclose gold cluster yields better therapeutic outcome than Remdesivir in COVID-19 hamster treatments as it is armed with direct inhibition viral replication and intrinsic suppression inflammatory cytokines expression. Crystal data reveals that Au (I), released from gold cluster (GA), covalently binds thiolate of Cys145 of SARS-CoV-2 M pro . GA directly decreases SARS-CoV-2 viral replication and intrinsically down-regulates NFκB pathway therefore significantly inhibiting expression of inflammatory cytokines in cells. The inflammatory cytokines in GA-treated COVID-19 transgenic mice are found to be significantly lower than that of control mice. When COVID-19 golden hamsters are treated by GA, the lung inflammatory cytokines levels are significantly lower than that of Remdesivir. The pathological results show that GA treatment significantly reduce lung inflammatory injuries when compared to that of Remdesivir-treated COVID-19 hamsters. Graphical Abstract: ga1 Highlights: Au ions, released from gold cluster, specifically bind thiolate of Cys145 of SARS-CoV-2 M pro. Gold cluster inhibit SARS-CoV-2 M pro activity and SARS-CoV-2 replication. Lung injury of gold cluster-treated COVID-19 hamsters are significantly lower than that of Remdesivir-treated COVID-19 hamsters.