Outcomes with culture-directed antibiotics following microvascular free tissue reconstruction for osteonecrosis of the jaw. (July 2022)

• Record Type: Journal Article
• Authors: Agarwal, Riddhima; Freeman, Taylor E.; Li, Michael M.; Naik, Akash N.; Philips, Ramez W.; Kang, Stephen Y.; Ozer, Enver; Agrawal, Amit; Carrau, Ricardo L.; Rocco, James W.; Old, Matthew O.; Seim, Nolan B.
• Is Part Of: Oral oncology. Volume 130(2022)
• Publication Date: 2022-07
• Subjects: Head and neck cancer -- Oral cancer -- Osteoradionecrosis -- Osteonecrosis -- Microvascular free tissue transfer -- Post-operative antibiotic therapy; ORNJ Osteoradionecrosis of the jaw -- BRONJ Bisphosphonate-related osteonecrosis of the jaw -- ORN Osteoradionecrosis -- HBO Hyperbaric oxygen -- MFTT Microvascular free tissue transfer -- OSU Ohio State University -- OR Operating room -- ID Infectious disease -- IV Intravenous; Mouth -- Cancer -- Periodicals; Mouth -- Tumors -- Periodicals; Mouth Diseases -- Periodicals; Mouth Neoplasms -- Periodicals; Bouche -- Cancer -- Périodiques; Bouche -- Tumeurs -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9943105
• DOI: 10.1016/j.oraloncology.2022.105878
• Languages: English
• ISSNs: 1368-8375

Abstract

Highlights: Osteoradionecrosis and bisphosphonate-related osteonecrosis of the jaw pose difficult treatment scenarios with higher complication rates. Long-term IV antibiotics directed by residual mandible cultures may decrease complication rates in free flap reconstruction of osteoradionecrosis. Free tissue transfer of non-irradiated, well-vascularized free tissue may improve tissue perfusion to the irradiated region as well as antibiotic delivery. Long-term IV antibiotics may provide benefit by treating Actinomyces. Abstract: Objectives: Radiation (ORNJ) and bisphosphonate-related (BRONJ) osteonecrosis of the jaw represent challenging entities to treat, with many patients requiring segmental resection and reconstruction with microvascular free tissue transfer (MFTT) in the setting of failed conservative therapy. Microvascular reconstruction is associated with higher post-operative complication rates when performed for advanced osteonecrosis versus oncologic defects. We hypothesize that basing antibiotic therapy on cultures obtained from the healthy bone marrow following resection during MFTT for ORNJ or BRONJ reduces rates of post-operative wound and surgical complications. Materials and methods: In a retrospective cohort study spanning January 2016 to October 2018, 44 patients undergoing MFTT for ORNJ or BRONJ were identified. Patients were categorized into two cohorts: residual healthy marrow culture (n = 11; RHM), treated with antibiotics guided by cultures from healthy appearing mandible, and all others (n = 33; AO), treated with antibiotics guided by cultures from resected necrotic bone or purulent drainage. Patient, reconstruction, and outcome variables were compared via appropriate statistical tools. Results: 81.8% of the RHM cohort versus 24.2% of the AO cohort received long-term IV antibiotics. Rates of post-operative wound complications, including those necessitating operative management, were significantly lower in the RHM cohort. Rates of flap failure were similar across both groups. Conclusion: Administration of long-term IV antibiotics directed by native mandible cultures may decrease complication rates following MFTT for ORNJ or BRONJ by treating residual, smoldering infection. Concurrently, transplantation of well-vascularized free tissue likely improves antibiotic delivery. Findings are crucial for the development of a standardized treatment algorithm following microvascular reconstruction for advanced osteonecrosis.