Brønsted acid-promoted three-component reaction of 2-methoxythiophene, sulfinates and water: Synthesis of γ-mercapto-β-sulfonyl esters. (22nd June 2022)

• Record Type: Journal Article
• Authors: Chen, Xianlie; Luo, Yixin; Zeng, Qingle
• Is Part Of: Tetrahedron letters. Volume 100(2022)
• Publication Date: 2022-06-22
• Subjects: Three-component reaction -- Brønsted acid -- Sulfinates -- γ-Mercapto-β-sulfonyl esters -- Synthesis -- Catalysis; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.153884
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A facile Brønsted acid-promoted three-component reaction of 2-methoxythiophene, sulfinates and water at room temperature has been discovered. Under the mild conditions, a series of γ- mercapto -β- sulfonyl esters were obtained in moderate to good yields. The control experiments support the reaction mechanism involves in three processes: 1, 5-H shift, Michael addition and ring opening in water.