Discovery of novel indole and indoline derivatives against Candida albicans as potent antifungal agents. (1st September 2022)

• Record Type: Journal Article
• Authors: Ma, Jia; Jiang, Yuan; Zhuang, Xinying; Chen, Huiting; Shen, Yunhong; Mao, Zewei; Rao, Gaoxiong; Wang, Ruirui
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 71(2022)
• Publication Date: 2022-09-01
• Subjects: Indole -- Indoline -- Antifungal activity -- Ras-cAMP-PKA pathway; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2022.128826
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: With the widespread use of azole antifungals in the clinic, the drug resistance has been emerging continuously. In this work, we have designed and prepared a series of novel indole and indoline derivatives, and in vitro antifungal activity against C. albicans were evaluated. The results showed that title compounds exhibited good antifungal effect on Azole-resistant C. albicans. Further mechanism study demonstrated that S18 could inhibit the biofilm formation and hyphae growth of C. albicans through the Ras-cAMP-PKA signaling pathway.