Sleep restriction alters cortical inhibition in migraine: A transcranial magnetic stimulation study. (July 2022)

• Record Type: Journal Article
• Authors: Mykland, Martin Syvertsen; Uglem, Martin; Neverdahl, Jan Petter; Øie, Lise Rystad; Meisingset, Tore Wergeland; Dodick, David W.; Tronvik, Erling; Engstrøm, Morten; Sand, Trond; Omland, Petter Moe
• Is Part Of: Clinical neurophysiology. Volume 139(2022)
• Page Start: 28
• Page End: 42
• Publication Date: 2022-07
• Subjects: Interictal migraine -- Silent period -- Intracortical facilitation -- Intracortical inhibition -- Pathophysiology -- Insufficient sleep; CS Conditioning stimulus -- CSP Cortical silent period -- EMG Electromyography -- ICF Intracortical facilitation -- ISI Interstimulus interval -- LICI Long-interval intracortical inhibition -- MA Migraine with aura -- MEP Motor evoked potential -- MwoA Migraine without aura -- NSM Non-sleep related migraine -- PAG Periaqueductal gray matter -- ppTMS Paired pulse transcranial magnetic stimulation -- REM Rapid eye movement sleep -- RMT Resting motor threshold -- rTMS Repetitive transcranial magnetic stimulation -- SAI Short-latency afferent inhibition -- SICI Short-interval intracortical inhibition -- SM Sleep related migraine -- SR Sleep restriction -- TMS Transcranial magnetic stimulation -- TS Test stimulus; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2022.04.004
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Reduced sleep alters central nervous inhibition from GABAergic and dopaminergic mechanisms differently in migraineurs and controls. Central nervous inhibition is differently affected by sleep changes in non-sleep related and sleep related migraine. Identifying sleep related subgroups of migraineurs could have implications for differentiated GABA or dopamine targeted treatment. Abstract: Objective: Migraine is a primary headache disorder with a well-known association with insufficient sleep. However, both the underlying pathophysiology of the disease and the relationship with sleep is still unexplained. In this study, we apply transcranial magnetic stimulation to investigate possible mechanisms of insufficient sleep in migraine. Methods: We used a randomised, blinded crossover design to examine 46 subjects with migraine during the interictal period and 29 healthy controls. Each subject underwent recordings of cortical silent period, short- and long-interval intracortical inhibition, intracortical facilitation and short-latency afferent inhibition after both two nights of habitual eight-hour sleep and two nights of restricted four-hour sleep. Results: We found reduced cortical silent period duration after sleep restriction in interictal migraineurs compared to controls (p = 0.046). This effect was more pronounced for non-sleep related migraine (p = 0.002) and migraine with aura (p = 0.017). The sleep restriction effect was associated with ictal symptoms of hypersensitivity such as photophobia (p = 0.017) and overall silent period was associated with premonitory dopaminergic symptoms such as yawning (p = 0.034). Conclusions: Sleep restriction reduces GABAergic cortical inhibition during the interictal period in individuals with migraine. Significance: Sleep related mechanisms appear to affect the pathophysiology of migraine and may differentiate between migraine subgroups.