Facile one-pot three-component strategy for the synthesis of 2-amino-4-arylthiazoles via elemental sulfur source. (22nd June 2022)

• Record Type: Journal Article
• Authors: Liang, Xiao-Ping; Luo, Min; Kang, Li; Tang, Long-Xing; Liang, Qing; Liu, Yuan-Lin; Yang, Zi; Zhang, Chun-Tao; Peng, Cai-Yun; Fu, Rong-Geng
• Is Part Of: Tetrahedron letters. Volume 100(2022)
• Publication Date: 2022-06-22
• Subjects: 2-amino-4-arylthiazole -- Elemental sulfur -- Three-component reaction -- Cyclization; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.153874
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A novel and facile metal-free method for the green synthesis of 2-amino-4-arylthiazole derivatives through the three-component cascade reaction of aromatic methyl ketones, elemental sulfur and cyanamide is reported. One CN bond and two CS bonds were formed in one-pot protocol without using catalysts.