Essential cues of engineered polymeric materials regulating gene transfer pathways. (July 2022)

• Record Type: Journal Article
• Authors: Ariful Islam, Mohammad; Park, Tae-Eun; Firdous, Jannatul; Li, Hui-Shan; Jimenez, Zuly; Lim, Michael; Choi, Jeong-Won; Yun, Cheol-Heui; Cho, Chong-Su
• Is Part Of: Progress in materials science. Volume 128(2022)
• Publication Date: 2022-07
• Subjects: Engineered materials -- Polymeric carriers -- Gene transfer pathways -- Cellular uptake regulation -- Intracellular trafficking; 66–34 br-OT 2:1 M mixture MUS: 3, 7 dimethyl octane 1-thiol -- 66–34 OT 2:1 M mixture of MUS and 1-octanethiol -- AEM·HCl 2-aminoethylmethacrylate hydrochloride -- AnnA1 annexin A1 -- APP aminopeptidase P -- ARF6 adenosine diphosphate ribosylation factor 6 -- BBB blood–brain barrier -- BPS biodegradable pH-sensitive surfactants -- Cav-1 caveolin-1 -- Cav-2 caveolin-2 -- CDC42 cell division cycle 42 -- Chol cholesterol -- CIE clathrin-independent endocytosis -- CLDPD cationic liposome-coated DNA/protamine/DNA -- CMCS carboxymethyl chitosan -- CME clathrin-mediated endocytosis -- Col collagen -- CPPs cell penetrating peptides -- CvME caveolae-mediated endocytosis -- DC 3β-N-(N, N-dimethylaminoethane)-carbamoyl -- DC6-14 O, O'-ditetradecanoyl-N-(alpha-trimethylammonioacetyl)diethanolamine chloride -- DNA deoxyribonucleic acid -- DOPE phosphoethanolamine -- DOTAP N-[1-(2, 3-dioleoyloxy)propyl]-N, N, N-trimethylammonium methyl-sulfate -- DPD dissipative particle dynamics -- DS degree of substitution -- ECM extracellular matrix -- FITC fluorescein isothiocyanate -- Fn fibrinogen -- GPI-APs glycosylphosphatidylinositol-anchored proteins -- GTPase guanosine triphosphatase -- His histidylated -- His-pLK histidylated polylysine -- HUVEC human umbilical vein endothelial cells -- LMWC low molecular weight chitosan -- mAnnaA1 monoclonal antibody to AnnaA1 -- mAPP monoclonal antibody to APP -- MSCs mesenchymal stem cells -- MUS 11-mercapto-1-undecanesulphonate -- MW molecular weight -- MWCNT multi-walled carbon nanotubes -- NPCS hydrophobically-modified chitosan nanoparticles -- NPs nanoparticles -- OPN osteopontin -- PAMAM poly(amidoamine) -- pAntp Drosophila Antennapedia -- PBAE poly(β-amino ester) -- pDNA plasmid DNA -- PEG polyethylene glycol -- PEI polyethylenimine -- PHPMA N-(2-hydroxy propyl)methacrylamide copolymer -- PI3K phosphatidylinositol 3 kinase -- PLGA poly(lactic-co-glycolic acid) -- PLL poly(L-lysine) -- PLT poly(lactitol-co-PEI) -- PRINT particle replication in non-wetting templates -- PSOAT polysorbitol transporter -- RVG rabies virus glycoprotein -- siOPN OPN siRNA -- siRNA small interfering ribonucleic acid -- TAT trans-activator of transcription -- TcdB Clostridium difficile toxin B -- XGC poly(xylitol-co-PEI) -- CRISPR-Cas9 clustered regularly interspaced short palindromic repeats-associated protein 9 -- SORT selective organ targeting; Materials science -- Periodicals; Science des matériaux -- Périodiques; 620.1105
• DOI: 10.1016/j.pmatsci.2022.100961
• Languages: English
• ISSNs: 0079-6425

Abstract

Abstract: Regulating cellular uptake pathways using engineered materials is becoming a vital strategy for efficient gene transfer because the success of gene delivery most often relies on the uptake mechanism and the intracellular fate of the delivery vectors. The uptake of gene carriers can be greatly affected by the various physical, geometrical, chemical, and biological characteristics of the delivery vectors. In the design of gene delivery materials, it is important to understand not only how gene carriers are taken up and transported into cells, but also how the uptake mechanism can be regulated. In this review, we discuss polymeric materials that regulate cellular uptake pathways for highly effective delivery of gene therapeutics, elucidate various routes of cellular uptake that alter the intracellular fate of polymeric gene carriers and finding efficient strategies for overcoming extracellular and intracellular obstacles. We also discuss the structures of polymeric materials in order to understand how they regulate cellular uptake. Lastly, we discuss various strategic approaches, including essential cues on how to regulate the cellular uptake pathways of polymeric carriers and how to control their endocytic trafficking to improve the efficacy of gene delivery.