Reduced neutralizing antibody response in naïve Covishield vaccinees against Omicron emphasizes booster vaccination. Issue 1 (July 2022)

• Record Type: Journal Article
• Authors: Yadav, Pragya D.; Sapkal, Gajanan N.; Sahay, Rima R.; Patil, Deepak Y.; Agrawal, Sachee; Adsul, Balkrishna; Tripathy, Srikanth; Deshpande, Gururaj R.; Nyayanit, Dimpal A.; Shete, Anita M.; Manraie, Manish; Kumar, Sanjay; Shastri, Jayanthi; Abraham, Priya
• Is Part Of: Journal of infection. Volume 85:Issue 1(2022)
• Page Start: 90
• Page End: 122
• Publication Date: 2022-07
• Subjects: Infection -- Periodicals; Bacterial Infections -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.905
• DOI: 10.1016/j.jinf.2022.04.031
• Languages: English
• ISSNs: 0163-4453

Abstract

Highlights: Immune response was assessed in the sera of covishield vaccinees. IgG response in naïve vaccinees was lesser than recovered and breakthrough cases. Neutralizing antibody titre for naïve vaccinees was lowest with omicron. Breakthrough cases demonstrated highest neutralizing antibody titre with omicron. The study demonstrated need for booster dose in naïve vaccinees.