Semi-automatic tumor segmentation of rectal cancer based on functional magnetic resonance imaging. (April 2022)

• Record Type: Journal Article
• Authors: Knuth, Franziska; Groendahl, Aurora R.; Winter, René M.; Torheim, Turid; Negård, Anne; Holmedal, Stein Harald; Bakke, Kine Mari; Meltzer, Sebastian; Futsæther, Cecilia M.; Redalen, Kathrine R.
• Is Part Of: Physics and imaging in radiation oncology. Volume 22(2022)
• Page Start: 77
• Page End: 84
• Publication Date: 2022-04
• Subjects: ADA Adaptive boosting -- DICE Sørensen-Dice similarity coefficient -- DME Dynamic multi echo -- DW Diffusion weighted -- IQR Interquartile range -- LDA Linear discriminant analysis -- MED Median -- MRI Magnetic resonance imaging -- MSD Mean symmetric surface distance -- SVM Support vector machines -- QDA Quadratic discriminant analysis; Radiotherapy -- Periodicals; Radiation dosimetry -- Periodicals; Cancer -- Imaging -- Periodicals; Oncology -- Periodicals; 615.842
• DOI: 10.1016/j.phro.2022.05.001
• Languages: English
• ISSNs: 2405-6316

Abstract

Graphical abstract: Highlights: Machine learning on magnetic resonance images (MRI) was used for tumor segmentation. Voxelwise machine learning with morphological post-processing achieved good segmentation results. Combining T2-weighted with functional MRI improved semi-automatic tumor segmentation. Dynamic contrast enhanced MRI was the most valuable functional MRI information. Tumor volume and interobserver variation were linked to measured segmentation quality. Abstract: Background and purpose: Tumor delineation is required both for radiotherapy planning and quantitative imaging biomarker purposes. It is a manual, time- and labor-intensive process prone to inter- and intraobserver variations. Semi or fully automatic segmentation could provide better efficiency and consistency. This study aimed to investigate the influence of including and combining functional with anatomical magnetic resonance imaging (MRI) sequences on the quality of automatic segmentations. Materials and methods: T2-weighted (T2w), diffusion weighted, multi-echo T2*-weighted, and contrast enhanced dynamic multi-echo (DME) MR images of eighty-one patients with rectal cancer were used in the analysis. Four classical machine learning algorithms; adaptive boosting (ADA), linear and quadratic discriminant analysis and support vector machines, were trained for automatic segmentation of tumor and normal tissue using different combinations of the MR images as input, followed by semi-automatic morphological post-processing. Manual delineations from two experts served as ground truth. The Sørensen-Dice similarity coefficient (DICE) and mean symmetric surface distance (MSD) were used as performance metric in leave-one-out cross validation. Results: Using T2w images alone, ADA outperformed the other algorithms, yielding a median per patient DICE of 0.67 and MSD of 3.6 mm. The performance improved when functional images were added and was highest for models based on either T2w and DME images (DICE: 0.72, MSD: 2.7 mm) or all four MRI sequences (DICE: 0.72, MSD: 2.5 mm). Conclusion: Machine learning models using functional MRI, in particular DME, have the potential to improve automatic segmentation of rectal cancer relative to models using T2w MRI alone.