Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort. Issue 6 (2nd June 2022)

• Record Type: Journal Article
• Authors: Svanes, Cecilie; Johannessen, Ane; Bertelsen, Randi Jacobsen; Dharmage, Shyamali; Benediktsdottir, Bryndis; Bråbäck, Lennart; Gislason, Thorarinn; Holm, Mathias; Jõgi, Oskar; Lodge, Caroline J; Malinovschi, Andrei; Martinez-Moratalla, Jesus; Oudin, Anna; Sánchez-Ramos, José Luis; Timm, Signe; Janson, Christer; Real, Francisco Gomez; Schlünssen, Vivi
• Other Names: author non-byline.; Callejas Francisco Javier author non-byline.; Godoy Raúl author non-byline.; Skorge Trude Duelien author non-byline.; Drengenes Christine author non-byline.; Jõgi Nils Oskar author non-byline.; Khomich Maryia author non-byline.; Kirkeleit Jorunn author non-byline.; Knudsen Toril Mørkve author non-byline.; Kuiper Ingrid author non-byline.; López-Cervantes Juan Pablo author non-byline.; Lønnebotn Marianne author non-byline.; Makvandi-Nejad Shokouh author non-byline.; Pérez Antonio author non-byline.; Røsland Anders author non-byline.; Shigdel Rajesh author non-byline.; Skulstad Svein Magne author non-byline.; Storaas Torgeir author non-byline.; Svanes Øistein author non-byline.; Triebner Kai author non-byline.; Tjalvin Gro author non-byline.; Vindenes Hilde author non-byline.; Xu Shanshan author non-byline.; Torén Kjell author non-byline.; Sanchez Jose Luis author non-byline.; Maldonado Jose author non-byline.; Lodge Caroline author non-byline.; Abramson Michael author non-byline.; Gurrin Lyle author non-byline.; Lowe Adrian author non-byline.; Martino David author non-byline.; Mishra Gita author non-byline.; Perret Jennifer author non-byline.; Thompson Bruce author non-byline.; Jõgi Nils Oskar author non-byline.; Jõgi Rain author non-byline.; Forsberg Bertil author non-byline.; Franklin Karl author non-byline.; Norbäck Dan author non-byline.; Lindberg Eva author non-byline.; Ekstrøm Magnus author non-byline.; Schlünssen Vivi author non-byline.; Cramer Christine author non-byline.; Pape Kathrine author non-byline.; Sigsgaard Torben author non-byline.; Lund Würtz Anne Mette author non-byline.; Accordini Simone author non-byline.; Calciano Lucia author non-byline.; Dratva Julia author non-byline.; Heinrich Joachim author non-byline.; Holloway John author non-byline.; Horsnell William author non-byline.; Jarvis Deborah author non-byline.; Krauss-Etchmann Susanne author non-byline.;
• Is Part Of: BMJ open. Volume 12:Issue 6(2022)
• Publication Date: 2022-06-02
• Subjects: Asthma -- Allergy -- Chronic airways disease -- EPIDEMIOLOGY -- PUBLIC HEALTH; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2021-059434
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Purpose: The Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort was established to (1) investigate how exposures before conception and in previous generations influence health and disease, particularly allergies and respiratory health, (2) identify susceptible time windows and (3) explore underlying mechanisms. The ultimate aim is to facilitate efficient intervention strategies targeting multiple generations. Participants: RHINESSA includes study participants of multiple generations from ten study centres in Norway (1), Denmark (1), Sweden (3), Iceland (1), Estonia (1), Spain (2) and Australia (1). The RHINESSA core cohort, adult offspring generation 3 (G3), was first investigated in 2014–17 in a questionnaire study (N=8818, age 18–53 years) and a clinical study (subsample, n=1405). Their G2 parents participated in the population-based cohorts, European Community Respiratory Heath Survey and Respiratory Health In Northern Europe, followed since the early 1990s when they were 20–44 years old, at 8–10 years intervals. Study protocols are harmonised across generations. Findings to date: Collected data include spirometry, skin prick tests, exhaled nitric oxide, anthropometrics, bioimpedance, blood pressure; questionnaire/interview data on respiratory/general/reproductive health, indoor/outdoor environment, smoking, occupation, general characteristics and lifestyle; biobanked blood, urine, gingival fluid, skin swabs; measured specific and total IgE, DNA methylation, sex hormones and oral microbiome. Research results suggest that parental environment years before conception, in particular, father's exposures such as smoking and overweight, may be of key importance for asthma and lung function, and that there is an important susceptibility window in male prepuberty. Statistical analyses developed to approach causal inference suggest that these associations may be causal. DNA methylation studies suggest a mechanism for transfer of father's exposures to offspring health and disease through impact on offspring DNA methylation. Future plans: Follow-up is planned at 5–8 years intervals, first in 2021–2023. Linkage with health registries contributes to follow-up of the cohort.