Fecal matter transplant from Ace2 overexpressing mice counteracts chronic hypoxia‐induced pulmonary hypertension. (10th January 2022)

• Record Type: Journal Article
• Authors: Oliveira, Aline C.; Yang, Tao; Li, Jing; Sharma, Ravindra K.; Karas, Marianthi K.; Bryant, Andrew J.; de Kloet, Annette D.; Krause, Eric G.; Joe, Bina; Richards, Elaine M.; Raizada, Mohan K.
• Is Part Of: Pulmonary circulation. Volume 12:Number 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-01-10
• Subjects: microbiota -- neuroinflammation -- renin angiotensin system and pathophysiology; Pulmonary circulation -- Periodicals; Pulmonary circulation; Electronic journals -- Sciences; Periodicals; 616.24005
• DOI: 10.1002/pul2.12015
• Languages: English
• ISSNs: 2045-8932

Abstract

Abstract: Recent evidence suggests pulmonary hypertension (PH), a disease of the pulmonary vasculature actually has multiorgan pathophysiology and perhaps etiology. Herein, we demonstrated that fecal matter transplantation from angiotensin‐converting enzyme 2 overexpressing mice counteracted the effects of chronic hypoxia to prevent pulmonary hypertension, neuroinflammation, and gut dysbiosis in wild type recipients.