Higher serum occludin after successful reperfusion Is associated with early neurological deterioration. (26th March 2022)

• Record Type: Journal Article
• Authors: Li, Weili; Yuan, Shuhua; Sui, Xueqin; Bian, Hetao; Wei, Ming; Chen, Zhiying; Shao, Haitao; Shi, Wenjuan; Shi, Shuhai; Ji, Xunming
• Is Part Of: CNS neuroscience & therapeutics. Volume 28:Number 7(2022)
• Page Start: 999
• Page End: 1007
• Publication Date: 2022-03-26
• Subjects: biomarker -- blood‐brain barrier -- early neurological deterioration -- endovascular thrombectomy -- occludin -- stroke; Neuropharmacology -- Periodicals; Central nervous system -- Diseases -- Effect of drugs on -- Periodicals; 612.8
• DOI: 10.1111/cns.13830
• Languages: English
• ISSNs: 1755-5930

Abstract

Abstract: Aims: Early neurological deterioration (END) is an important factor that affects prognosis in patients with acute ischemic stroke. We explored the relationship between serum occludin levels after successful reperfusion and END in patients treated with endovascular thrombectomy (EVT). Methods: We prospectively enrolled 120 stroke patients who underwent EVT with successful reperfusion. Enzyme‐linked immunosorbent assay was used to detect the serum occludin levels on admission and within 1 h after successful reperfusion. Receiver operating characteristic curves (ROC) and regression analysis were used to compare the relationship between serum occludin and END after thrombectomy. Results: Among the 120 patients, 36 (30%) experienced END. The END group had higher serum occludin levels than the non‐END group after successful reperfusion [4.31 (3.71–5.38) vs 6.32 (5.88–6.99), p < 0.001]. The ROC curve showed that postoperative serum occludin levels had a significant prediction value for END (AUC: 0.86, p < 0.001). Regression analysis showed that serum occludin was an independent risk factor for END in EVT patients (adjusted odds ratio: 4.46, 95% confidence interval: 1.92–10.32; p < 0.001). Conclusions: The higher serum occludin levels were strongly related to END after successful reperfusion. Serum occludin may be an independent risk factor for END in EVT patients. Abstract : This study makes a significant contribution because it provides novel evidence that the higher serum occludin levels after successful reperfusion could predict the risk of END in the next 24–48 h. It also indicates that blood–brain barrier damage during reperfusion may be an important risk factor for END in the future.