Is there a role for HSF1 in viral infections?. Issue 6 (10th May 2022)

• Record Type: Journal Article
• Authors: Reyes, Antonia; Navarro, Areli J.; Diethelm‐Varela, Benjamín; Kalergis, Alexis M.; González, Pablo A.
• Other Names: López‐Lastra Marcelo guestEditor.
• Is Part Of: FEBS open bio. Volume 12:Issue 6(2022)
• Page Start: 1112
• Page End: 1124
• Publication Date: 2022-05-10
• Subjects: heat shock -- heat shock factor 1 -- HSF1 -- stress -- viral infections; Molecular biology -- Periodicals; Cytology -- Periodicals; Life sciences -- Periodicals; Biological Science Disciplines -- Periodicals; Molecular Biology -- Periodicals; Cell Biology -- Periodicals; Cytology; Life sciences; Molecular biology; Periodicals; 572.805
• DOI: 10.1002/2211-5463.13419
• Languages: English
• ISSNs: 2211-5463

Abstract

Abstract : Cells undergo numerous processes to adapt to new challenging conditions and stressors. Heat stress is regulated by a family of heat shock factors (HSFs) that initiate a heat shock response by upregulating the expression of heat shock proteins (HSPs) intended to counteract cellular damage elicited by increased environmental temperature. Heat shock factor 1 (HSF1) is known as the master regulator of the heat shock response and upon its activation induces the transcription of genes that encode for molecular chaperones, such as HSP40, HSP70, and HSP90. Importantly, an accumulating body of studies relates HSF1 with viral infections; the induction of fever during viral infection may activate HSF1 and trigger a consequent heat shock response. Here, we review the role of HSF1 in different viral infections and its impact on the health outcome for the host. Studying the relationship between HSF1 and viruses could open new potential therapeutic strategies given the availability of drugs that regulate the activation of this transcription factor. Abstract : Heat shock factor 1 (HSF1) plays important roles in the replication cycle of viruses. Numerous viruses have been found to modulate, or to be affected by the activation of HSF1. Depending on the virus, HSF1 can lead to detrimental effects over the virus (red line) or confer advantages to the virus (green arrows). Understanding the interplay between HSF1 and viral infections could help identify novel pharmacological targets for the development of antiviral therapeutic approaches.