Difficult maintenance of serum drug concentration in methicillin‐resistant Staphylococcus aureus toxic shock syndrome during early puerperium. Issue 6 (21st March 2022)

• Record Type: Journal Article
• Authors: Shibata, Takashi; Nakago, Satoshi; Kato, Hiroki; Tokuda, Hisato; Hosono, Sayoko; Kotsuji, Fumikazu
• Is Part Of: Journal of obstetrics and gynaecology research. Volume 48:Issue 6(2022)
• Page Start: 1484
• Page End: 1488
• Publication Date: 2022-03-21
• Subjects: cesarean section -- infection -- methicillin‐resistant staphylococcus aureus -- puerperium -- toxic shock syndrome; Gynecology -- Periodicals; Obstetrics -- Periodicals; 618.1005
• DOI: 10.1111/jog.15221
• Languages: English
• ISSNs: 1341-8076

Abstract

Abstract: Toxic shock syndrome can be caused by methicillin‐resistant Staphylococcus aureus (MRSA). During puerperium this condition is rare, and proper treatment during this period has not been clarified. Two patients developed toxic shock syndrome caused by MRSA soon after cesarean section. Despite the administration of antibiotics, both developed severe conditions and one of them required hysterectomy. The dosage was adjusted in the same way as nonpregnancy, but the actual drug concentration was significantly different from expectation. When there is severe infection during the early postpartum period, maintaining drug concentration at optimal levels may be difficult, and this could be life‐threatening. Better understanding of the pharmacokinetics and establishment of a method to determine the optimal drug dose during puerperium is required.