Infantile Inflammatory Myofibroblastic Tumor of Spleen. (1st June 2022)

• Record Type: Journal Article
• Authors: Thirunavukkarasu, Balamurugan; Roy, Pritam Singha; Gupta, Kirti; Sekar, Aravind; Bansal, Deepak
• Is Part Of: Fetal and pediatric pathology. Volume 41:Number 3(2022)
• Page Start: 475
• Page End: 479
• Publication Date: 2022-06-01
• Subjects: Inflammatory myofibroblastic tumor -- ALK -- Epstein–Barr virus -- spleen -- ROS1; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.1080/15513815.2020.1836098
• Languages: English
• ISSNs: 1551-3815

Abstract

Abstract: Background: Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm with unknown etiology and recurrent potential. They are widely reported in children and young adults. Nearly 50% of inflammatory myofibroblastic tumor harbor rearrangement in anaplastic lymphoma kinase ( ALK ) gene with the majority expressing ALK protein. ALK-negative IMTs harbor alteration in ROS1 gene in a subset of cases. Few reports have shown association of IMT with Epstein–Barr virus (EBV). Case report: We report a case of IMT of the spleen in an 18-month-old infant presenting with abdominal distention and failure to thrive. Workup for ALK-1, ROS1, and EBV small-encoded RNA in-situ hybridization using immunohistochemistry was negative. Conclusions: IMT can arise in an infant spleen.