Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C. Issue 11 (19th May 2022)

• Record Type: Journal Article
• Authors: Messa, Francesco; Dilauro, Giuseppe; Paparella, Andrea Nicola; Silvestri, Lavinia; Furlotti, Guido; Iacoangeli, Tommaso; Perrone, Serena; Salomone, Antonio
• Is Part Of: Green chemistry. Volume 24:Issue 11(2022)
• Page Start: 4388
• Page End: 4394
• Publication Date: 2022-05-19
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/d2gc00636g
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : The in situ generation of H2 from aluminum powder and water/KOH enabled a general hydrogenation method in cholinium chloride/glycerol deep eutectic solvent under Pd/C catalysis. Abstract : A general, safe and scalable reductive protocol, based on the in situ generation of H2 from aluminum and water, has been developed in deep eutectic solvents for the reduction of many organic compounds under Pd-catalysis. The methodology has been efficiently applied to the multigram-scale synthesis of benzindopyrine as an active pharmaceutical ingredient.