Orbital analysis of bonding in diarylhalonium salts and relevance to periodic trends in structure and reactivity. Issue 22 (19th May 2022)

• Record Type: Journal Article
• Authors: Karandikar, Shubhendu S.; Bhattacharjee, Avik; Metze, Bryan E.; Javaly, Nicole; Valente, Edward J.; McCormick, Theresa M.; Stuart, David R.
• Is Part Of: Chemical science. Volume 13:Issue 22(2022)
• Page Start: 6532
• Page End: 6540
• Publication Date: 2022-05-19
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d2sc02332f
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : A revised bonding model for diarylhalonium salts, that involves partial s-orbital contribution, provides new insight into periodic trends in structure and reactivity. Abstract : Diarylhalonium compounds provide new opportunities as reagents and catalysts in the field of organic synthesis. The three center, four electron (3c–4e) bond is a center piece of their reactivity, but structural variation among the diarylhaloniums, and in comparison with other λ 3 -iodanes, indicates that the model needs refinement for broader applicability. We use a combination of Density Functional Theory (DFT), Natural Bond Orbital (NBO) Theory, and X-ray structure data to correlate bonding and structure for a λ 3 -iodane and a series of diarylchloronium, bromonium, and iodonium salts, and their isoelectronic diarylchalcogen counterparts. This analysis reveals that the s-orbital on the central halogen atom plays a greater role in the 3c–4e bond than previously considered. Finally, we show that our revised bonding model and associated structures account for both kinetic and thermodynamic reactivity for both acyclic phenyl(mesityl)halonium and cyclic dibenzohalolium salts.