Cobalt-catalysed CH-alkylation of indoles with alcohols by borrowing hydrogen methodology. Issue 11 (17th May 2022)

• Record Type: Journal Article
• Authors: Zhou, Bei; Ma, Zhuang; Alenad, Asma M.; Kreyenschulte, Carsten; Bartling, Stephan; Beller, Matthias; Jagadeesh, Rajenahally V.
• Is Part Of: Green chemistry. Volume 24:Issue 11(2022)
• Page Start: 4566
• Page End: 4572
• Publication Date: 2022-05-17
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/d2gc00469k
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : A general heterogeneous cobalt-catalysed CH-alkylation of indoles with alcohols is reported. Abstract : A general heterogeneous cobalt-catalysed CH-alkylation of indoles with alcohols is reported. Utilizing this straightforward borrowing hydrogen methodology, a series of substituted and functionalized indoles were easily coupled with benzylic, heterocyclic, and aliphatic alcohols including methanol to prepare >65 substituted indoles in good to excellent yields. The resulting products represent an interesting class of heterocyclic compounds widely used in organic synthesis and medicinal chemistry. Key for this synthesis is the use of specific cobalt-nanoparticles supported on N-doped carbon, which were conveniently prepared by the pyrolysis of a templated material generated in situ by mixing cobalt-nitrate, zinc-nitrate, 2, 6-diaminopyridine, and colloidal silica, and subsequent removal of silica.