Base-promoted direct E-selective olefination of organoammonium salts with sulfones toward stilbenes and conjugated 1, 3-dienes. Issue 21 (16th May 2022)

• Record Type: Journal Article
• Authors: Zhang, Tao; Wang, Runji; Chen, Jiani; Liu, Long; Huang, Tianzeng; Li, Chunya; Tang, Zhi; Chen, Tieqiao
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 21(2022)
• Page Start: 4369
• Page End: 4375
• Publication Date: 2022-05-16
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob00716a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A base-promoted direct deaminative olefination of organoammonium salts was developed. Abstract : A base-promoted direct deaminative olefination of organoammonium salts was developed. Only mediated by KO t Bu, a series of benzyl and cinnamyl ammonium salts reacted smoothly with sulfones, producing the valuable stilbenes and related 1, 3-diene derivatives in good to high yields with good functional group tolerance and excellent E -selectivity. With this developed method, biologically active resveratrol and DMU-212 were also successfully prepared, which further demonstrates the practicality of this reaction.