Promoting exogenous repair in multiple sclerosis: myelin regeneration. Issue 3 (June 2022)

• Record Type: Journal Article
• Authors: Bezukladova, Svetlana; Genchi, Angela; Panina-Bordignon, Paola; Martino, Gianvito
• Is Part Of: Current opinion in neurology. Volume 35:Issue 3(2022)
• Page Start: 313
• Page End: 318
• Publication Date: 2022-06
• Subjects: exogenous repair -- multiple sclerosis -- remyelination -- stem cells; Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.805
• DOI: 10.1097/WCO.0000000000001062
• Languages: English
• ISSNs: 1473-6551

Abstract

Abstract : Purpose of the review: Despite the significant progress in the development of disease-modifying treatments for multiple sclerosis (MS), repair of existing damage is still poorly addressed. Current research focuses on stem cell-based therapies as a suitable alternative or complement to current drug therapies. Recent findings: Myelin damage is a hallmark of multiple sclerosis, and novel approaches leading to remyelination represent a promising tool to prevent neurodegeneration of the underlying axon. With increasing evidence of diminishing remyelination capacity of the MS brain with ageing and disease progression, exogenous cell transplantation is a promising therapeutic approach for restoration of oligodendrocyte precursor cell pool reserve and myelin regeneration. Summary: The present review summarizes recent developments of remyelinating therapies in multiple sclerosis, focusing on exogenous cell-based strategies and discussing related scientific, practical, and ethical concerns.