Multi-method global sensitivity analysis of mathematical models. (7th August 2022)

• Record Type: Journal Article
• Authors: Dela, An; Shtylla, Blerta; de Pillis, Lisette
• Is Part Of: Journal of theoretical biology. Volume 546(2022)
• Publication Date: 2022-08-07
• Subjects: Modeling -- Global parameter sensitivity analysis -- eFAST -- Sobol's method -- Derivative-based global sensitivity measures -- HIV model -- Tumor growth model; Biology -- Periodicals; Biological Science Disciplines -- Periodicals; Biology -- Periodicals; Biologie -- Périodiques; Theoretische biologie; Biology; Periodicals; 571.05
• DOI: 10.1016/j.jtbi.2022.111159
• Languages: English
• ISSNs: 0022-5193

Abstract

Graphical abstract: Highlights: Selecting appropriate parameter sensitivity methods poses significant challenges. We develop a framework that employs and compares three different methods. We provide an intuitive understanding of each method via MATLAB codes. A guide for tuning algorithm parameters is created and presented. New methodology demonstrated on models of HIV progression and tumor growth. Abstract: Increasingly-sophisticated parameter-sensitivity analysis techniques continue to be developed, and each technique comes with its own set of advantages and disadvantages. Selecting which parameter-sensitivity method to use for a particular model, however, is not a straightforward task. In this work, we present a multi-method framework that incorporates three global sensitivity analysis methods: two variance-based methods and one derivative-based method. The two variance-based methods are Sobol's method and MeFAST . The derivative-based method is known as DGSM (Derivative-based Global Sensitivity Measures). MeFAST (Multi test eFAST) is a new parameter sensitivity analysis implementation we built upon the eFAST (Extended Fourier Amplitude Sensitivity Test) algorithm. The improvements incorporated into MeFAST address some important aspects of prior eFAST implementations. We present an intuitive description of each implemented algorithm along with MATLAB codes and a guide to tuning algorithm hyper-parameters for better efficiency. We demonstrate the full methodology and workflow using two example mathematical models of different complexity: the first is a model of HIV disease progression and the second is a model of tumor growth. The computational framework we provide generates graphics for visualizing and comparing the results of all three sensitivity analysis algorithms (DGSM, Sobol, and MeFAST). This algorithm output comparison tool allows one to make a more informed decision when assessing which parameters most importantly influence model outcomes.