Signal Transduction Strategies for Analyte Detection Using DNA‐Based Nanostructures. (29th April 2022)

• Record Type: Journal Article
• Authors: Lee, Seungheon; Godhulayyagari, Shivudu; Nguyen, Shadler T.; Lu, Jasmine K.; Ebrahimi, Sasha B.; Samanta, Devleena
• Is Part Of: Angewandte Chemie. Volume 134:Number 24(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-04-29
• Subjects: Aptamers -- Biosensors -- DNA Nanostructures -- Detection -- Signal Transduction; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202202211
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: The use of DNA‐based nanostructures as probes has led to significant advances in chemical and biological sensing, allowing the detection of analytes in complex media, the understanding of fundamental biological processes, and the ability to diagnose diseases based on molecular signatures. The utility of these structures arises both from DNA's inherent ability to selectively recognize and bind a variety of chemical species and from the unique properties observed when DNA is restructured at the nanoscale. In this Minireview, we chronicle the most commonly used signal transduction strategies that have been interfaced with various DNA‐based nanostructures. We discuss the types of analytes and the detection scenarios that are sought after, delineate the advantages and disadvantages of each signaling strategy, and outline the key considerations that guide the selection of each signaling method. Abstract : The various signal transduction strategies that are employed in chemical and biological sensing with DNA‐based nanostructures are the focus of this Minireview. The relative advantages and disadvantages of these different methods are also discussed and the considerations that determine the ideal strategy for a given application are delineated.