T‐cell prolymphocytic leukemia is associated with deregulation of oncogenic microRNAs on transcriptional and epigenetic level. Issue 7 (29th March 2022)

• Record Type: Journal Article
• Authors: Patil, Paurnima; Hillebrecht, Sina; Chteinberg, Emil; López, Cristina; Toprak, Umut H.; Seufert, Julian; Bernhart, Stephan H.; Kretzmer, Helene; Bergmann, Anke K.; Bens, Susanne; Högel, Josef; Müller, Annika; Jebaraj, Billy Michael; Schrader, Alexandra; Johansson, Patricia; Costa, Dolors; Schlesner, Matthias; Dürig, Jan; Herling, Marco; Campo, Elias; Stilgenbauer, Stephan; Wiehle, Laura; Siebert, Reiner
• Is Part Of: Genes, chromosomes & cancer. Volume 61:Issue 7(2022)
• Page Start: 432
• Page End: 436
• Publication Date: 2022-03-29
• Subjects: epigenetic -- genomic -- micro‐RNAs -- T‐cell prolymphocytic leukemia -- T‐cells; Cancer -- Genetic aspects -- Periodicals; 616.994042
• DOI: 10.1002/gcc.23034
• Languages: English
• ISSNs: 1045-2257

Abstract

Abstract: Deregulation of micro(mi)‐RNAs is a common mechanism in tumorigenesis. We investigated the expression of 2083 miRNAs in T‐cell prolymphocytic leukemia (T‐PLL). Compared to physiologic CD4+ and CD8+ T‐cell subsets, 111 miRNAs were differentially expressed in T‐PLL. Of these, 33 belonged to miRNA gene clusters linked to cancer. Genomic variants affecting miRNAs were infrequent with the notable exception of copy number aberrations. Remarkably, we found strong upregulation of the miR‐200c/‐141 cluster in T‐PLL to be associated with DNA hypomethylation and active promoter marks. Our findings suggest that copy number aberrations and epigenetic changes could contribute to miRNA deregulation in T‐PLL.