Impaired glucose tolerance is associated with enhanced postprandial pancreatic polypeptide secretion. Issue 5 (19th April 2022)

• Record Type: Journal Article
• Authors: Zhao, Yanyun; Zhou, Yue; Xiao, Min; Huang, Yajing; Qi, Mengmeng; Kong, Zili; Chi, Jingwei; Che, Kui; Lv, Wenshan; Dong, Bingzi; Wang, Yangang
• Is Part Of: Journal of diabetes. Volume 14:Issue 5(2022)
• Page Start: 334
• Page End: 344
• Publication Date: 2022-04-19
• Subjects: glucose tolerance -- islet function -- pancreatic polypeptide -- T2DM; 2型糖尿病 -- 糖耐量 -- 胰多肽 -- 胰岛功能; Diabetes -- Periodicals; 618.3646005
• DOI: 10.1111/1753-0407.13268
• Languages: English
• ISSNs: 1753-0393

Abstract

Abstract: Background: The purpose of this study is to compare serum pancreatic polypeptide (PP), insulin, C‐peptide, and glucagon in different glucose tolerance stages; analyze the influencing factors of PP secretion; and further explore the role of PP in the pathogenesis of diabetes mellitus. Methods: Data were collected from 100 subjects from hospital. According to the results of oral glucose tolerance test (OGTT), the subjects were divided into a normal glucose tolerance (NGT) group, an impaired glucose regulation (IGR) group, and a newly diagnosed type 2 diabetes mellitus (T2DM) group. PP and the related parameters were measured, and the area under the curve (AUC) 120 min after OGTT was calculated. AUCpp ( AUC of PP) was used as the dependent variable and the potentially influencing factors were used as the independent variable for multiple linear regression analysis. Results: Postprandial 60 min PP in the IGR group was higher than those in the NGT group (2973.80 [±547.49] pg·h/mL vs 2663.55 [±594.89] pg·h/mL, p < 0.05). AUCpp was significantly higher in the IGR group (428.76 pg·h/mL, 95% confidence interval [CI] [41.06 –816.46], p = 0.031) and newly diagnosed T2DM group (404.35 pg·h/mL, 95% CI [5.37–803.33], p = 0.047) than in the NGT group. AUCpp was negatively correlated with body mass index (BMI) (r = −0.235, p = 0.038) and positively correlated with postprandial 60 min blood glucose (r = 0.370, p = 0.001) and AUCbg (AUC of blood glucose) (r = 0.323, p = 0.007). Multiple linear regression analysis indicated that there was a linear correlation between BMI, AUCbg, and AUCpp ( p = 0.004, p = 0.001), and the regression equation was calculated as: AUCpp = 6592.272 + 86.275 × AUCbg ‐95.291 × BMI (R 2 = 12.7%, p < 0.05). Conclusions: Compared with NGT subjects, IGR and T2DM patients have an enhanced postprandial PP secretion. In T2DMs, the secretion of PP is mainly affected by BMI and blood glucose. Abstract : Highlights Compared with normal glucose tolerance subjects, impaired glucose regulation and type 2 diabetes mellitus (T2DM) patients have an enhanced postprandial pancreatic polypeptide (PP) secretion. In patients with T2DM, the secretion of PP is mainly affected by body mass index and blood glucose. There may exist a potential protective effect of PP on the function of isletcells. 摘要: 背景: 本研究旨在比较不同糖耐量阶段血清胰多肽(PP)、胰岛素、C‐肽、胰高血糖素的变化, 分析影响胰多肽分泌的因素, 进一步探讨胰多肽在糖尿病发病机制中的作用。 方法: 收集100例住院患者的临床资料。根据口服糖耐量试验(OGTT)结果, 将受试者分为糖耐量正常(NGT)组、糖调节受损(IGR)组和新诊断的2型糖尿病(T2D)组。测量脉压及相关指标, 计算餐后2小时曲线下面积(AUC)。以AUCpp(PP AUC)为因变量, 潜在影响因素为自变量进行多元线性回归分析。 结果: IGR组餐后60 分钟PP高于NGT组(2973.80±547.49)pg·h/mLvs 2663.55[±594.89]pg·h/mL, p < 0.05)。AUCpp在IGR组(428.76 pg·h/ml, 95%可信区间[CI][41.06‐816.46], p=0.031)和初诊T2D组(404.35 pg·h/ml, 95%CI[5.37‐803.33], p=0.047)显著高于NGT组。AUCpp与体重指数(BMI)呈负相关(r=−0.235, p=0.038), 与餐后60 分钟血糖(r=0.370, p=0.001)和AUCbg(血糖AUC)呈正相关(r=0.323, p=0.007)。多元线性回归分析显示, 体重指数、AUCbg与AUCpp呈线性相关(p =0.004, p =0.001), 回归方程为:AUCpp=6592.272 + 86.275 × AUCbg‐95.291 × BMI(R2=12.7%, p < 0.05)。 结论: 与NGT患者相比, IGR和T2 D患者餐后PP分泌增加。在T2D中, PP的分泌主要受BMI和血糖的影响。