Bioactive Film‐Guided Soft–Hard Interface Design Technology for Multi‐Tissue Integrative Regeneration. Issue 15 (23rd March 2022)

• Record Type: Journal Article
• Authors: Li, Yamin; Chen, Can; Jiang, Jia; Liu, Shengyang; Zhang, Zeren; Xiao, Lan; Lian, Ruixian; Sun, Lili; Luo, Wei; Tim‐yun Ong, Michael; Yuk‐wai Lee, Wayne; Chen, Yunsu; Yuan, Yuan; Zhao, Jinzhong; Liu, Changsheng; Li, Yulin
• Is Part Of: Advanced science. Volume 9:Issue 15(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-23
• Subjects: artificial ligament -- biomimetic film -- osseointegration -- tissue regeneration -- translational potential; Science -- Periodicals; 505
• DOI: 10.1002/advs.202105945
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: Control over soft‐to‐hard tissue interfaces is attracting intensive worldwide research efforts. Herein, a bioactive film‐guided soft–hard interface design (SHID) for multi‐tissue integrative regeneration is shown. Briefly, a soft bioactive film with good elasticity matchable to native ligament tissue, is incorporated with bone‐mimic components (calcium phosphate cement, CPC) to partially endow the soft‐film with hard‐tissue mimicking feature. The hybrid film is elegantly compounded with a clinical artificial ligament to act as a buffer zone to bridge the soft (ligament) and hard tissues (bone). Moreover, the bioactive film‐decorated ligament can be rolled into a 3D bio‐instructive implant with spatial‐controllable distribution of CPC bioactive motifs. CPC then promotes the recruitment and differentiation of endogenous cells in to the implant inside part, which enables a vascularized bone growth into the implant, and forms a structure mimicking the biological ligament–bone interface, thereby significantly improving osteointegration and biomechanical property. Thus, this special design provides an effective SHID‐guided implant‐bioactivation strategy unreached by the traditional manufacturing methods, enlightening a promising technology to develop an ideal SHID for translational use in the future. Abstract : A elastomeric film is bioactivated by calcium phosphate cement (CPC)‐incorporation, which is then compounded with clinical artificail ligament to form a soft‐hard‐interface mesh. The mesh can be rolled into a 3D bio‐instructive implant with spatial‐controllable distribution of CPC, a structure efficiently facilitates multi‐tissue integrative regeneration by inducing vascular and new bone ingrowth.