Phosphorylation of Yun is required for stem cell proliferation and tumorigenesis. Issue 5 (18th April 2022)

• Record Type: Journal Article
• Authors: Ren, Xuejing; Zhao, Hang; Shi, Lin; Li, Zhengran; Kong, Ruiyan; Ma, Rui; Jia, Lemei; Lu, Shan; Wang, Jian‐Hua; Dong, Meng‐qiu; Wang, Yingchun; Li, Zhouhua
• Is Part Of: Cell proliferation. Volume 55:Issue 5(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-04-18
• Subjects: Cell proliferation -- Periodicals; 571.84
• DOI: 10.1111/cpr.13230
• Languages: English
• ISSNs: 0960-7722

Abstract

Abstract: Stem cells maintain adult tissue homeostasis under physiological conditions. Uncontrolled stem cell proliferation will lead to tumorigenesis. How stem cell proliferation is precisely controlled is still not fully understood. Phosphorylation of Yun is essential for ISC proliferation. Yun is essential for the proliferation of normal and transformed intestinal stem cells. Our mass spectrometry and biochemical data suggest that Yun can be phosphorylated at multiple residues in vivo. Interestingly, we show that the phosphorylation among these residues is likely interdependent. Furthermore, phosphorylation of each residue in Yun is important for its function in ISC proliferation regulation. Thus, our study unveils the important role of post‐translational modification of Yun in stem cell proliferation. Abstract : Yun (Luck in Chinese) is an intrinsic factor identified for intestinal stem cell (ISC) proliferation control. Yun is post‐translational modified by phosphorylation at five serine residues at its C‐terminus in vivo. Phosphorylation among these five residues is likely interdependent. Importantly, phosphorylation of each residue in Yun is important for Yun's function in ISC proliferation regulation.