Outcomes of lung metastasis from pancreatic cancer: A nationwide multicenter analysis. (6th March 2022)

• Record Type: Journal Article
• Authors: Homma, Yuki; Endo, Itaru; Matsuyama, Ryusei; Sho, Masayuki; Mizuno, Shugo; Seyama, Yasuji; Hirano, Satoshi; Aono, Takashi; Kitami, Chie; Morita, Yoshifumi; Takeda, Yutaka; Yoshida, Kazuhiro; Tani, Masaji; Kaiho, Takashi; Yamamoto, Yuzo; Aoki, Hideki; Ogawa, Masao; Niguma, Takefumi; Mataki, Yuko; Kawasaki, Hiroshi; Baba, Hideo; Yokomizo, Hiroshi; Rikiyama, Toshiki; Yamaue, Hiroki; Yamamoto, Masakazu
• Is Part Of: Journal of hepato-biliary-pancreatic sciences. Volume 29:Number 5(2022)
• Page Start: 552
• Page End: 561
• Publication Date: 2022-03-06
• Subjects: lung metastasis -- pancreatic cancer; Liver -- Diseases -- Periodicals; Biliary tract -- Diseases -- Periodicals; Pancreas -- Diseases -- Periodicals; 617.556
• DOI: 10.1002/jhbp.1127
• Languages: English
• ISSNs: 1868-6974

Abstract

Abstract: Background: Although distant metastasis from pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, some single center studies reported that lung metastasis has a favorable prognosis. The aim of this study is to evaluate the prognostic value of site‐specific metastasis after pancreatectomy for PDAC, with a focus on lung metastasis. Methods: Data from 117 cases of lung metastasis after pancreatectomy were collected retrospectively from 23 institutions in Japan. To compare the sites of metastasis we also collected the data of 134 patients with liver only metastasis, 67 patients with peritoneal only metastasis and 121 patients with locoregional recurrence alone. Results: In patients with lung only metastasis, the median time from recurrence to death (RTD) was 23.1 months, which was better in comparison to other sites of recurrence. In lung metastasis group, the patients who underwent pulmonary resection had better long‐term outcomes in comparison to those who did not. (RTD: 29.2 vs 15.2, P < .001). In the multivariate analysis, solitary metastasis (HR 5.03; 95% CI 1.195‐21.144, P = .022) and postoperative chemotherapy (HR 14.089; 95% CI 1.729‐114.77, P = .023) were identified as significant prognostic factors after lung resection. Conclusions: Surgical resection is a favorable option for selected patients with a solitary lung metastasis and for whom adjuvant chemotherapy can be administrated. Abstract : Highlight Homma and colleagues revealed that patients with lung metastases from pancreatic cancer had a better prognosis than those with liver, peritoneal or local recurrence in this retrospective multicenter analysis. Pulmonary resection was a favorable option for selected patients with a solitary lung metastasis to whom adjuvant chemotherapy could be administered.