Cover Picture: Membrane Cholesterol Depletion Enhances Enzymatic Activity of Cell‐Membrane‐Coated Metal‐Organic‐Framework Nanoparticles (Angew. Chem. Int. Ed. 24/2022). Issue 24 (16th May 2022)

• Record Type: Journal Article
• Authors: Wang, Shuyan; Kai, Mingxuan; Duan, Yaou; Zhou, Zhidong; Fang, Ronnie H.; Gao, Weiwei; Zhang, Liangfang
• Is Part Of: Angewandte Chemie international edition. Volume 61:Issue 24(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-16
• Subjects: Cell Membrane Coating -- Cholesterol -- Metal-Organic-Framework -- Nanoparticle -- Protein Delivery; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202206436
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Enhancement of the enzymatic activity of cell‐membrane‐coated metal–organic framework nanoparticles by depleting membrane cholesterol is demonstrated by Weiwei Gao, Liangfang Zhang et al. in their Communication (e202203115 ). Increased membrane permeability, caused by the reduction in cholesterol level, is likely responsible for the increased enzymatic activity. This discovery broadens the use of these biomimetic nanoparticles in drug delivery and biodetoxification.