Surface Engineering of Lipid Vesicles Based on DNA Nanotechnology. Issue 5 (23rd May 2022)

• Record Type: Journal Article
• Authors: Hao, Pengyan; Niu, Liqiong; Luo, Yuanyuan; Wu, Na; Zhao, Yongxi
• Is Part Of: ChemPlusChem. Volume 87:Issue 5(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-23
• Subjects: DNA nanotechnology -- membranes -- proteins -- surface engineering -- vesicles; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cplu.202200074
• Languages: English
• ISSNs: 2192-6506

Abstract

Abstract: Lipid vesicle research is of great significance in the field of biomedicine and great progress has been made in recent years, in which the surface engineering on lipid membranes plays an important role. By introducing new active sites on membrane surface, the physicochemical properties of vesicles are regulated and the biological functions are extended. DNA nanotechnology is an excellent tool for surface engineering of vesicles and has attracted more and more attention. In this Review, the interaction between DNA and lipid membrane is presented. Subsequently, recent advances in the applications of vesicle‐surface‐engineering based on DNA nanotechnology are highlighted. DNA nanostructures are used to mimic membrane proteins in the system of artificial liposome vesicles. Surface‐engineered extracellular vesicles (EVs) based on DNA nanotechnology are applied to achieve non‐invasive early screening of diseases with high sensitivity and precision. Finally, challenges and prospects for future development in this field are discussed. Abstract : The interaction between DNA and lipid membranes is discussed in this Review article. The discussion covers DNA nanotechnology that has been applied on the surface engineering of lipid vesicles; the physicochemical properties of vesicles have been modulated by simulating membrane proteins, and the physiological behavior and biological function of vesicles have been studied by mimicking membrane proteins. Surface‐engineered extracellular vesicles (EVs) based on DNA nanotechnology enable high‐sensitivity and high‐precision non‐invasive early screening of diseases.