Surgical outcomes in patients with endoscopic versus transcranial approach for skull base malignancies: a 10-year institutional experience. (2nd January 2022)

• Record Type: Journal Article
• Authors: Rutland, John W.; Gill, Corey M.; Ladner, Travis; Goldrich, David; Villavisanis, Dillan F.; Devarajan, Alex; Pai, Akila; Banihashemi, Amir; Miles, Brett A.; Sharma, Sonam; Balchandani, Priti; Bederson, Joshua B.; Iloreta, Alfred M.; Shrivastava, Raj K.
• Is Part Of: British journal of neurosurgery. Volume 36:Number 1(2022)
• Page Start: 79
• Page End: 85
• Publication Date: 2022-01-02
• Subjects: Skull base surgery -- malignancy -- endoscopic surgery -- transcranial surgery -- gross total resection; Nervous system -- Surgery -- Periodicals; 617.48
• DOI: 10.1080/02688697.2020.1779659
• Languages: English
• ISSNs: 0268-8697

Abstract

Abstract: Object: The authors performed an extensive comparison between patients treated with open versus an endoscopic approach for skull base malignancy with emphasis on surgical outcomes. Methods: A single-institution retrospective review of 60 patients who underwent surgery for skull base malignancy between 2009 and 2018 was performed. Disease features, surgical resection, post-operative morbidities, adjuvant treatment, recurrence, and survival rates were compared between 30 patients who received purely open surgery and 30 patients who underwent purely endoscopic resection for a skull base malignancy. Results: Of the 60 patients with skull base malignancy, 30 underwent open resection and 30 underwent endoscopic resection. The most common hisotype for endoscopic resection was squamous cell carcinoma (26.7%), olfactory neuroblastoma (16.7%), and sarcoma (10.0%), and 43.3%, 13.3%, and 10.0% for the open resection cohort, respectively. There were no statistical differences in gross total resection, surgical-associated cranial neuropathy, or ability to achieve negative margins between the groups ( p > 0.1, all comparisons). Patients who underwent endoscopic resection had shorter surgeries (320.3 ± 158.5 minutes vs. 495.3 ± 187.6 minutes ( p = 0.0003), less intraoperative blood loss (282.2 ± 333.6 ml vs. 696.7 ± 500.2 ml ( p < 0.0001), and shorter length of stay (3.5 ± 3.7 days vs. 8.8 ± 6.0 days ( p < 0.0001). Additionally, patients treated endoscopically initiated adjuvant radiation treatment more quickly (48.0 ± 20.3 days vs. 72.0 ± 20.5 days ( p = 0.01). Conclusions: An endoscopic endonasal approach facilitates a clinically meaningful improvement in surgical outcomes for skull base malignancies.