Aspects of green chemistry toward synthesis of benzazoles and quinoxalines: Bovine serum albumin-water system for C–N/C–S bond formation. Issue 6 (19th March 2022)

• Record Type: Journal Article
• Authors: , Saima; Lavekar, Aditya G.; Equbal, Danish; Sinha, Arun K.
• Is Part Of: Synthetic communications. Volume 52:Issue 6(2022)
• Page Start: 834
• Page End: 848
• Publication Date: 2022-03-19
• Subjects: Biocatalyst -- bovine serum albumin (BSA) -- benzazoles -- oxidative cyclo-condensation -- quinoxalines; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2022.2053160
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: In this report, a biocatalytic divergent approach of therapeutically important five-membered benzazole heterocyclic compounds such as benzothiazoles and benzimidazoles has been described wherein Bovine serum albumin (BSA) and water play cooperative role for oxidative cyclo-condensation reaction between 2-mercapto/amino anilines and aromatic aldehydes under air at room temperature. Further, this green strategy also extended for the synthesis of privileged and biologically important six membered quinoxalines, 2-phenylimidazo [1, 2-a]pyridine and benzo[d]imidazo[2, 1-b]thiazoles. Moreover, the present biocatalytic protocol for the synthesis of such five- and six-membered heterocyclic compounds also have the added benefits of high atom economy, operational simplicity, excellent yields, recyclability (up to four cycles), and gram scalability. Graphical abstract: UF0001